We assessed efficacy of spraying pesticides from an unmanned helicopter to control two insect species, Monochamus alternatus and M. saltuarius, which are vectors of pine wood nematodes. Control efficacy of thiacloprid FL (33×), acetamiprid ME (33×), and flupyradifurone SL (33×) was determined by placing caged insects in the canopy of pine trees (Pinus sp). Water-sensitive paper was used to record the spray pattern of pesticide droplets and the degree of coverage; furthermore, we investigated peripheral scattering due to spraying. The three pesticides showed > 96% control efficacy against the targeted vectors, and pesticide droplet spray patterns were similar. Peripheral scattering was observed up to 20 m in front and 10 m to the left, right, and behind the targeted area. The coverage index of all the directions at 5 and 10 m distance was 6-7 and 2, respectively.