The purpose of this research is to evaluate patient's satisfaction and clinician' knowledge level about pain, nausea, vomiting, and temperature management of patients after operation by develop an web-based evidence-based practice guideline about pain, nausea, vomiting, and temperature control after operation in order to apply the guideline operation patients. The collected data was analyzed through real number, average, standard deviation, t-test and repeated ANOVA by using SPSS/WIN 17.0 program. The study subjects showed a significant difference in the level of knowledge about pain, nausea/vomiting, and temperature control after operation and patient's satisfaction, before and after applying the web-based evidence-based practice guideline.