It is necessary to use prestressed modal analysis to calculate the modal frequencies and mode shapes of a prestressed structure such as a spinning blade, a preloaded structure, or a thermally deformed pipe, because the prestress effect sometimes causes significant changes in the frequencies and mode shapes. When the finite element model under consideration has a very large number of degrees of freedom, repeated prestressed modal analyses for investigating the prestress effects might become too computationally expensive to finish within a reasonable design-process time. To alleviate these computational difficulties, a Krylov subspace-based model order reduction, which reduces the number of degrees of freedom of the original finite element model and speeds up the necessary prestressed modal analysis with the reduced order models (ROMs), is presented. The numerical process for the moment-matching model reduction is performed directly on the full order models (FOMs) (modeled in ANSYS) by the Arnoldi process. To demonstrate the advantages of this approach for performing prestressed modal analysis, the prestressed wheel and the compressor impeller under their high-speed rotation are considered as examples.