• Title, Summary, Keyword: 갱년기 증상

Search Result 125, Processing Time 0.049 seconds

Effect of a Mixed Extract of Fenugreek Seeds and Lespedeza cuneata on Testosterone Deficiency Syndrome (호로파와 야관문 복합추출물의 남성갱년기 개선에 관한 연구)

  • Lee, Kyeong Soo;Lee, Eun Kyung;Kim, Shin Yeon;Kim, Tae Hwan;Kim, Hyun Pyo
    • Korean Journal of Food Science and Technology
    • /
    • v.47 no.4
    • /
    • pp.492-498
    • /
    • 2015
  • Testosterone deficiency syndrome (TDS) is normally observed in elderly men and is a clinical and biochemical syndrome, characterized by a decline in plasmic testosterone levels resulting in a significant decrease in quality of life. The aim of this study was to evaluate the effect of a mixed extract of fenugreek seeds and Lespedeza cuneata (YHM) on TDS. Rats were divided into three groups: the negative control, YHM-40 (40 mg/kg), and YHM-80 (80 mg/kg) groups. After 4 weeks of YMH administration, an increase was observed in the plasmic testosterone levels, vastus lateralis muscular strength, forced swimming time, total sperm counts, and motile sperm counts in YHM-40 and YHM-80 groups compared to the negative control group. Moreover, sex hormone binding globulin, the epididymal fat pad, total plasmic cholesterol, and triglyceride levels were significantly decreased in the YHM-fed groups. However, prostate specific antigen, aspartate aminotransferase, and alanine aminotransferase levels did not differ among the groups. These results suggest that YHM may enhance testosterone levels in elderly men and alleviate TDS without common side effects.

Establishment of the Male Menopause Animal Model Using Rats (랫드를 활용한 남성갱년기 동물모델의 확립)

  • Lee, Su Jung;Kwon, Gyoo Taik;Choi, Hye Ran;Gim, Sung Woong;Choi, Do Hyun;Kong, Hyun Seok;Kwon, Ji Woong;Shin, Daekeun;Lee, Sang Jin
    • Journal of agriculture & life science
    • /
    • v.52 no.5
    • /
    • pp.91-100
    • /
    • 2018
  • The level of testosterone in the blood decreases in males with age, resulting in menopausal symptoms. As the rat reproductive system is very similar to humans, the rats(Ratus norvegicus) commonly used in scientific studies, have been domesticated for more than one hundred years. Therefore, in order to establish an animal model of male menopause, this study was conducted to obtain data on the changes in major hormones and biochemical changes, including testosterone and weight changes in reproductive organs in the two groups of 22 and 50 weeks old rats. The weights of body and reproductive organs were greater at 50 weeks of age than at 22 weeks of age. However, DHT level in serum was higher at 22 weeks than at 50 weeks. In addition, significant increase in AST, ALP, total protein, triglyceride and total cholesterol levels was detected at 50 weeks. The levels of testosterone, LH and sperm concentration and motilitywereremarkably decreased in 50 weeks old rats. The serum FSH level did not change between the two groups. Therefore, it appears that 50 weeks old rats are appropriate and eligible as an animal model of male menopause. Further studies are needed to confirm the changes in various factors according to periods of growth through continuous experiments.

Development of mobile-application based cognitive training for Menopausal Women with Cognitive Complaints (갱년기 여성을 위한 앱 기반의 인지기능훈련 프로그램 개발)

  • Kim, Ji-Hyun
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.21 no.5
    • /
    • pp.150-166
    • /
    • 2020
  • Based on the theory of cognitive reserve, we undertook this study to develop a cognitive function training program for woman in menopausal transition with complaints of declining in cognitive function. The program was established by applying the analysis, design, and development stages of the network-based instructional system designed by Jung. The cognitive function training program developed by us is an was an 8-week program composed of cognitive and video training using a mobile application. The program consists of 24 sessions, each with 20-30 minutes of duration, to be completed 3 sessions per week. The contents of the cognitive function training comprise of memory, attention, language function, and scenario-based problem-solving for executive functions, all of which are cognitive areas found to be the most vulnerable for menopausal women. The educational contents were developed for eight subject areas, one subject area per week, including the definition of menopause, its causes and symptoms, menopause and brain function, etc. During the pilot test, the cognitive function training program was applied to 10 menopausal women who complained of cognitive function decline. The results indicated that, after eight weeks of training, the overall cognitive function of participants increased, revealing statistically significant differences (t=-3.04, p=.014) after the program was completed. The mobile app-based cognitive function training program might not only improve patients' memory functions but also potentially reduce the incidence of dementia.

Effect of Fermented Cirsium japonicum Extract on Testosterone Deficiency Syndrome (엉겅퀴 발효 추출물을 통한 남성 갱년기 증상 개선 효과)

  • Jeong, Byung Seo;Kim, Seong Hoon;Kim, Hyun Pyo
    • Journal of the Korean Society of Food Science and Nutrition
    • /
    • v.46 no.7
    • /
    • pp.790-800
    • /
    • 2017
  • As men get older, total testosterone levels decline gradually, and concentrations of free and bioavailable testosterone decline sharply with each decade beyond their 30s. Andropause or testosterone deficiency syndrome (TDS) is defined as a decrease in sexual satisfaction or decline in general well-being accompanied by low levels of testosterone in older men. This male climacteric is characterized by nervousness, reduced potency, decreased libido, irritability, fatigue, depression, memory problems, sleep disturbances, and hot flushes. Cirsium japonicum (CJ) is used as a traditional medicine for hemorrhage, blood congestion, and inflammation in Korea. However, there is no report on the efficacy of CJ treatment for TDS. In this study, we observed the mitigating effect of CJ extract (CE) and fermented CJ extract (FCE) on symptoms of TDS. In elderly male rats, total and testosterone levels, hind limbs muscles, forced swimming time, and total and motile sperm counts significantly increased after daily intake of CE and FCE for 6 weeks. In contrast, sex hormone binding globulin, retroperitoneal fat, total serum cholesterol, and triglyceride levels were significantly reduced in CE and FCE groups. However, there was no difference in prostate specific antigen, aspartate aminotransferase, and alanine aminotransferase levels among all groups, which means CE and FCE did not have putative adverse effects. In a cell experiment, we also observed that CE and FCE enhanced expression of genes related to testosterone biosynthesis but reduced genes involved in testosterone conversion. On the whole, these positive effects on TDS were greater in FCE compared to CE. Thus, these results suggest the potential of FCE as a promising natural product for recovering testosterone levels and alleviating TDS.

Comparisons of Body Image, Depression, and Climacteric Symptoms among Middle-Aged Women with and without Thyroidectomy (갑상선절제술을 받은 중년여성과 받지 않은 중년여성의 신체상, 우울, 갱년기 증상 비교)

  • Yun, Byeong Sook;Back, Ji Eun;Lee, June Sang;Park, Mi Jeong;Lim, Young Mi
    • Journal of Korean Clinical Nursing Research
    • /
    • v.14 no.3
    • /
    • pp.5-14
    • /
    • 2008
  • Purpose: The purpose of this study was to compare body image, depression, and climacteric symptoms among middle-aged women with and without thyroidectomy. Method: The research design was a comparative descriptive study using a self-report questionnaire. A total of 102 women aged 40~59 years were recruited using a convenient sampling method. A total of 52 women out of 102 were within a year after thyroidectomy due to benign disease. The rest of the subjects were healthy women without any previous diseases in thyroid. The instruments included Body Image Concern Inventory, Climacteric symptoms, and Center for Epidemiological Studies Depression Scale. The data were analyzed by descriptive statistics, t-test, $x^2$-test, one-way ANOVA, and correlation analysis. Results: There were no significantly differences in age, education, menstruation states between women with and without thyroidectomy. The demographic characteristics of two groups were homogeneous. There were significantly statistical differences in body image (t= 8.456, p=.000), and depression (t=3.142, p=.002) between the groups. There was, however, no significantly differences of climacteric symptoms. In addition, in women with thyroidectomy, no significant associations were found among body image, depression, and climacteric symptoms. Conclusion: The findings demonstrated the need to develop an effective nursing intervention to increase body image and to reduce depression in middle-aged women after thyroidectomy.

  • PDF

A Study on Climacteric Symptoms, Depression and Quality of Life in Middle-Aged Women (일지역 중년여성의 갱년기증상, 우울, 삶의 질에 대한 연구)

  • Park, Hyoung-Sook;Kim, Sang-Keum;Cho, Gyoo-Yeong
    • Korean Journal of Women Health Nursing
    • /
    • v.9 no.4
    • /
    • pp.479-488
    • /
    • 2003
  • Purpose: The purpose of this study was to identify the relationship between self reported climacteric symptoms, and depression, and the quality of life in middle aged women. Method: The subjects of this study were 149 women from 40 to 64 years of age. Climacteric symptoms were measured with Neugarton's tool(1965) and depression with Zung's tool. Quality of life was related to self reported climacteric symptoms were education level (F=3.011, p=.035), income measured by Rho's tool(1988). Result: The general characteristic variables significantly level (F=2.670, p=.057), income satisfaction (F=3.413. p=.011), perceived subjective health condition(F=28.623, p=.000). The general characteristic variables significantly related to depression were age(t=-2.476, p=.014), education level (F=4.492, p.013). income satisfaction (F=2.845, p.026), perceived subjective health condition (F = 8.468, p=.000). The general characteristics variables significantly related to quality of life were income level (F= 5.010, p=.000), income satisfaction (F=6.314, p=.000), perceived subjective health condition (F=3.516, p<=.032). menstruation cycles(t=-2.66, p=.023). The relationship between self reported climacteric symptoms and depression had a statistically a positive correlation (r=.357, p=.000). The relationship between depression and quality of life had a statistically with a negative correlation(r=-.397, p=.000). Conclusion: These results may contribute to a better understanding of depression and quality of life in middle aged women. Therefore, health programs for prompting climacteric women´s health should be a planned based on results of the study.

  • PDF

The Relationship Among Urinary Incontinence, Menopausal Symptom and Life Satisfaction in Middle Aged Women (일 지역 중년여성의 요실금.갱년기 증상과 생활만족도와의 관계)

  • Lim, Hyun-Ja
    • Korean Journal of Women Health Nursing
    • /
    • v.7 no.2
    • /
    • pp.157-168
    • /
    • 2001
  • The purpose of this study was to investigate of the relationship of the urinary incontinence, menopausal symptom and life satisfaction in middle aged women. The subjects of this study were 235 middle aged women, living in M city, during the period from June 21 to August 31, 2000. The instruments for this study were the urinary incontinence modified and adding by Lee Young Sook(1994), the menopausal symptom developed by Song Ae Ri and Chung Eun Soon(1998) and the life satisfaction translated and modified by Suh Kyung Hee(1988). Collected data were analyzed using descriptive statistics, t-test, ANOVA, Pearson correlation coefficients and stepwise multiple regression with SAS package. The result of this are as follows : 1. The total mean score of urinary incontinence was $1.56{\pm}0.58$ with a range of 0 to 4. The mean score on the menopausal symptom was $2.05{\pm}0.43$ with a range of 1 to 4. The mean life satisfaction score was $1.14{\pm}0.41$ with a range of 0 to 2. 2.General characteristics ralated to urinary incontinence were age and numbers of children (F=7.66, p=0.000, F=2.86, p=0.037). General characteristics ralated to menopausal symptom were age (F=7.37, p=0.000), occupation (t=5.33, p=0.021), problem of children (t=6.46, p=0.011) and marital satisfaction (F=5.65, p=0.004). General characteristics ralated to life satisfaction were type of housing (t=12.06, p=0.000), problem of children (t=6.96, p=0.008) and marital satisfaction (F=18.86, p=0.000). 3.The urinary incontinence and menopausal symptom were correlated positively (r=.235, p=.000). The urinary incontinence and life satisfaction were correlated negatively (r=-.114, p=.007). The menopausal symptom and life satisfaction were correlated negatively (r=-.277, p=.000). 4.The menopausal symptom, type of housing and marital satisfaction explained 16.6% of the variance for life satisfaction in the middle aged women.

  • PDF

Self-reported Climacteric Symptoms, Self concept and Depression in Middle-Aged Women (중년여성의 갱년기 증상, 자아개념 및 우울간의 관계)

  • Sung, Mi-Hae
    • Korean Journal of Adult Nursing
    • /
    • v.14 no.1
    • /
    • pp.102-113
    • /
    • 2002
  • Purpose: This study was designed to identify the relationship between self reported climacteric symptoms, self concept and depression in middle aged women. Method: Data were collected through self-reported questionaires which were constructed to include a climacteric symptoms, self-concept and depression of middle-aged women scale. The subjects for this study were 102 women between 40-59 years of age living in P city. The data were analyzed by descriptive statistics, t-test, ANOVA, Pearson Correlation Coefficient. Results: The results obtained from this study were as follows : 1) The relationship between self reported climacteric symptoms and self concept was statistically significant with a negative correlation (r=-0.4862, P0.001). The relationship between self reported climacteric symptoms and depression had a statistically significant positive correlation (r=0.5393, P<0.001). The Relationship between self-concept and depression had a statistically significant negative correlation (r=-0.3769, P<0.001). 2) General characteristic variables significantly related to self reported climacteric symptoms were age (F=3.13, P<0.05) and frequency of pregnancy (F=3.24, P<0.05). General characteristic variables significantly related to frequency of self-concept were age (F=3.13, P<0.05), education level (F=2.97, P<0.05) and occupation (t=1.84, P<0.05). General characteristic variables significantly related to depression were age (F=3.12, P<0.05) and number of children (t=3.59, P<0.05). 3) The obstetrical characteristic variable significantly related to self-reported climacteric symptoms was the frequency of pregnancy (t=3.24, P<0.05). Conclusion: This study shows possible implications for nursing intervention for middle-aged women's health to prevent and relieve climacteric symptoms.

  • PDF

The Effects of Estrogen Replacement Therapy on Blood Pressure, Heart Rate Variability, and Climacteric Symptoms in Postmenopausal Women (에스트로젠 호르몬 대치요법이 혈압, 심박동변이, 갱년기증상에 미치는 효과)

  • Lee, Hae-Kyung
    • Korean Journal of Women Health Nursing
    • /
    • v.8 no.2
    • /
    • pp.151-164
    • /
    • 2002
  • PURPOSE: Estrogen replacement therapy is indicated for the relief of hot flushes and urogenital atrophy, the prevention of osteoporosis and the reduction in risk of cardiovascular disease. The present study assessed by blood pressure, heart rate variability, and climacteric symptoms in menopausal women before treatment and at 1 month during estrogen replacement therapy. METHODS: The study sample consisted of 16 healthy menopausal women (range 49 to 59 years, mean : 53.4 years) attending menopausal clinics for the complaint of climateric symptoms at S. hospital in Chunchoen. They were all non-smokers and no patient had symptoms or evidence of cardiovascular disease. They took estrogen replacement therapy (conjugated estrogen 0.625 mg with or without medroxy progesteron 2.5mg) for 1 month. Blood pressure, heart rate variability(heart period and vagal tone) through ECG, and climacteric symptom were measured in all subjects before treatment and at 1 month during treatment. Climacteric symptom questionnaire which was developed by Neugarten et al.(1963) was modified with 20 items of question(Cronbach's alpha = 88 -.89). The data was collected from Sept. 1. 2000 to July. 30. 2001. RESULTS: There was no significant difference in mean systolic and diastolic pressure between the baseline and at 1 month during treatment. The mean heart period and vagal tone were slightly increased, but difference of mean heart period and vagal tone were not statistically significant between the baseline and at 1 month during treatment. The score of climacteric symptoms decreased significantly from the baseline after treatment. CONCLUSIONS: Even though, this study did not show that estrogen replacement therapy led decrease of blood pressure and increase heart rate variability, climacteric symptoms reduced much in all subjects after taking drugs. These results suggest that there is need to repeat study with long term period.

  • PDF