The purpose of this study is to investigate the relationship andropause symptoms, stress, self-esteem and quality of life among middle-aged men. The data were collected from Jun to August 2017. The subjects were 40 to 60 year old males residing in Y city and 198 questionnaires were analyzed. A menopausal man's quality of life was significantly different according to final education, monthly income, exercise status, the scores of quality of life was negatively correlated with those of andropause symptoms and stress, but positively correlated with those of self-esteem. The result of adding six variables that have significantly different quality of life, factors influencing quality of life are self-esteem, stress, andropause symptoms, monthly income and analysis result, explaining 52.3% of the variance. Therefor, The results of this study through repeated research in the future, it will contribute to the development and application of a nursing arbitration program to improve the quality of life for men in menopause.