• 제목, 요약, 키워드: 갱년기 증상

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한방병원에 내원하는 갱년기 여성의 체성분 특성과 Menopause Rating Scale(MRS), The Menopause-specific Quality of Life Questionnaire(MENQOL)을 통한 증상에 대한 상관도 분석 (A Study on the Relationship between Body Composition and Menopause Rating Scale (MRS), The Menopause-specific Quality of Life Questionnaire (MENQOL) of Postmenopausal Women)

  • 박강인;박연경;박경선;황덕상;이창훈;장준복;이진무
    • 대한한방부인과학회지
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    • v.28 no.1
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    • pp.85-91
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    • 2015
  • Objectives: Postmenopausal symptoms are subject to many factors. Recently, obesity has been suggested as a factor of hot flush. So this study aims to report the relationship between body composition and Menopause Rating Scale (MRS), The Menopause-specific Quality of Life Questionnaire (MENQOL) of postmenopausal women. Methods: We studied 42 climacteric women who had visited Kyung Hee University Hospital at Gangdong from April 2011 to July 2014. 42 women had filled out MRS, MENQOL, and they had taken body composition tests. Pearson correlation tests were conducted. (Correlation was statistically significant at the 0.05 level) Results: Correlation between psychological subscale of MENQOL and Waist-Hip Ratio (WHR) was statistically significant (pearson correlation coefficient=0.385; p-value=0.012). But other subscales of MRS and MENQOL were not statistically related with body composition. Conclusions: WHR could be an important factor of psychological health of menopausal women. So, abdominal fat reduction must be considered when curing menopausal symptoms. In connection with climacteric depression, well-designed studies would be necessary.

골담초 열수 추출물의 갱년기 이후 지질 및 당질 대사 개선 효능 (Effects of a Caragana sinica Water Extract on Lipid and Glucose Metabolism in Ovariectomized Rats)

  • 이상철;정수임;강미영
    • 한국자원식물학회지
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    • v.29 no.5
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    • pp.532-538
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    • 2016
  • 난소의 노화에 의해 폐경이 시작되면 에스트로겐 분비가 중단되어 여러 폐경 증상들을 겪게 되는데 이것으로 인해 발병되는 성인병 질환에 대한 치료 또는 예방에 대한 연구가 활발히 진행되고 있다. 본 연구의 목적은 난소절제술을 통해 폐경을 유도한 흰 쥐 모델에서 골담초 열수 추출물의 체내 물질 대사 관련 여부 및 개선 효과를 검토하기 위하여 실험을 수행하였다. Sprague-Dawley 암컷 쥐30마리를 비절제난소군(SHAM), 난소제거군(OVX) 그리고 골담초 추출물을 급여한 OVX-CS군으로 각각 10리씩 나누어 8주간 사육하였다. 체중 및 체중증가량 그리고 지방조직무게는 OVX군에서 유의적으로 증가하였으며 OVX-CS 군에서 감소하였다. 에스트로겐 결핍으로 인한 혈장 중성지질, 총콜레스테롤 수준은 골담초 추출물 급여에 따라 감소하고 HDL 콜레스테롤 수준은 증가하였다. 또한 지방산 합성 관련 효소 활성도인 ME는 간조직에서는 OVX-CS군에서 유의적으로 감소하였고 G6PD 활성은 OVX 군들 간에는 차이가 없었다. 당신생합성 관련 효소인 G6pase 활성은 골담초 추출물 섭취에 따라 억제되는 것으로 나타났다. 혈장 아디포카인 측정 결과 렙틴 농도는 OVX-CS군이 정상군 수치만큼 감소하였으며, 아디포넥틴도 정상수준으로 증가하였다. 이상의 결과로 난소제거를 통해 폐경이 유도된 흰쥐모델에서 골담초 추출물 급여가 에스트로겐 결핍으로 인한 체중증가를 억제하고, 지질 및 당질 대사에 긍정적인 영향을 미쳐 건강기능성 소재로서의 가능성이 높은 것으로 보이며, 추후 골담초의 구체적인 생활성물질을 추적하여 그 과학적 기전을 밝히는 것이 필요하다고 판단된다.

갱년기 여성의 안면홍조 증상에 대한 국내 한의학 연구 동향 분석 (A Review on Domestic Study Trends on Hot Flush in Menopausal Women with Traditional Korean Medicine)

  • 홍누리;장영숙;양수현;최윤영;오다윤;이수진;남궁진;김진환
    • 대한한방부인과학회지
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    • v.33 no.1
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    • pp.86-103
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    • 2020
  • Objectives: The purpose of this study is to analyse the domestic trends of Traditional Korean Medicine on Hot flush in menopausal women. Methods: We searched six databases and selected relevant papers according to the criteria. Results: 12 papers included case report, literature review, randomized controlled clinical trials (RCTs), Non-RCTs, and retrospective chart analysis study design. 1. The daily diary, Kupperman's Index, Menopause Rating Scale, Menopause-specific Quality of Life Questionnaire, Digital Infrared Thermographic Imaging were used as a measure of the symptoms of hot flush. 2. There were significant correlations between Thermographic images, Pulse energy, Lifestyle Habits, Low frequency power/High frequency power (LF/HF) ratio and certain items of Menopausal Symptoms Measurement. 3. The case report using Er-Xian decoction and Hwangryunhaedoktang-Gamibang showed significant effect. 4. Domestic RCT studies using herbal or acupuncture treatments showed a significant value of 3.4 on average in the quality assessment conducted in the study. However, the number of domestic studies included was five, which is not enough compared to foreign countries. Conclusions: This study examined domestic research trends on hot flushes of menopausal women and found that various evaluation tools and diagnostic methods were applied. It is necessary to conduct various RCT studies in Korea, where the number of studies is insufficient compared to overseas.

In vitro 검출 시스템을 이용한 한약재 열수 및 에탄올 추출물의 남성호르몬 유사활성 검출 (Detection of Testosterone-like Activities of Hydrothermal and Ethanol Extracts of Oriental Medicines Using an in Vitro Detection System)

  • 이동근;조정권;이상현
    • 생명과학회지
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    • v.30 no.6
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    • pp.550-554
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    • 2020
  • 이 연구의 목적은 시험관내 TCD (테스토스테론 화합물 검출) 시스템으로 8개 한약재의 테스토스테론 유사 활성을 검색하는 것이었다. 녹각상, 백수오, 야관문, 홍삼, 토령, 민들레, 남가세, 호로파의 열수 추출물과 80% 에탄올 추출물을 5, 50, 500 ㎍/ml의 농도로 in vitro TCD 시스템에 적용하였다. 80% 에탄올 추출물의 테스토스테론 유사 활성은 일반적으로 농도에 비례하였고, 음성대조군보다 0.9 내지 5.0 배 더 높았다. 호로파와 야관문은 동일한 농도에서 우수한 테스토스테론 유사 활성을 보였으며 민들레와 홍삼이 그 뒤를 이었다. 토령과 남가세는 낮은 테스토스테론 유사 활성을 보였으며 녹각상과 백수오는 매우 낮은 활성을 나타냈다. 양성대조군 5α-DHT의 활성과 비교하면, 호로파 및 야관문의 80% 에탄올 추출물은 500 ㎍/ml에서 10-8 M 5α-DHT보다 높은 테스토스테론 유사 활성을 나타냈다. 열수 추출물은 80% 에탄올 추출물보다 낮은 테스토스테론 유사 활성을 보였고, 농도에 따른 활성의 증가도 에탄올 추출물보다 낮았다. 호로파, 야관문 및 민들레 등의 80% 에탄올 추출물이 테스토스테론 관련 유전자의 전사 효율을 향상시킬 수 있음이 확인되었다. 따라서, 본 연구는 남성 갱년기 증상의 개선에 필요한 건강 기능성 식품 재료 또는 의약 재료를 개발하는 데 참고가 될 수 있을 것이다.

갱년기 증상과 생활스트레스의 관계에 관한 연구 (An Analytical Study of the Relationship between Climacteric Symptoms and the Stress of Life Events)

  • 임은옥
    • 한국보건간호학회지
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    • v.8 no.2
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    • pp.1-34
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    • 1994
  • This study has been done in order to analyze the relationship between climacteric symptoms and the stress of life events. For the purpose of this study. objectives set up were as followings. : 1. Climacteric symptoms complained by middle aged women are studied. 2. The stress of life events experienced by middle aged women is studied. 3. The relationship between climacteric symptoms and the stress of life events is studied. 4. The relationship between climacteric symptoms and general characteristics is studied. and the relationship between the stress of life events and general characteristics is also studied. The sample size of this study was 462 cases. The subjects were middle-aged women. who were from 40 to 60 years old and resided in Seoul. Data were collected by using questionnaires which consisted of 122 questions from Jan. 1 to Feb. 7 in 1992. The questionnaires include questions about general characteristics. climacteric symptoms and life events. The measurement scales for this study were adopted from the climacteric symptoms scale developed by Chi. Sung-Ai and the measurement scale of stress related to life events devised by Lee. Pyoung Sook. The analysis of data collected was done by using SPSS-pc package. Firstly. general characteristics were analyzed by using descriptive statistical methods. Secondly. climacteric symptoms were analyzed by using descriptive statistical methods. the analysis of variance and correlation analysis. Thirdly. the stress of life events was studied by using descriptive statistical methods. the analysis of variance. and tests of independence. The results of this study are as followings. 1. General characteristics of the respondents are as followings: The average age is 49. 13. and the age group from 46 to 50 has $30.5\%$ in the respondents. Christianity is the major religion $(42.6\%)$. and the respondents with a high school diploma are $(43.1\%)$ of the respondents. $60\%$ of all respondents are housewives. and $90.5\%$ are married. The average number of children is 2.71. and the average number of family is 4.24 Monthly income of $39.1\%$ of the respondents is from l,010,000 Won to 2,000,000 Won. The premenopausal group is $4.9\%$. and $45.5\%$ of all respondents are satisfied with marrital life. $43.3\%$ of all feel happy. and $13.9\%$ feel economic frustration. $27.9\%$ of respondents are satisfied with sexual life. and $45\%$ of all report that the amount of recreational activities are more needed. 2. The average score of climacteric symptoms is 1. 8461 (The maximum score is 5.0). The symptoms complained frequently are nervousness. muscle-ache. fatigue. headache and knee-ache. Climacteric symptoms are significantly different in menopausal states. age groups. the number of children, marrital satisfaction. the feeling of life. self-reported health states and sexual satisfaction. 3. The life events occurred frequently were 'discord with husband', 'children's important exams', 'separation from husband related to works' and 'vacation'. When life events are analyzed by factors. the most frequently mentioned factor is 'marrital life'. The stress of life events is significantly different in a few general characteristics (age. the number of children, the number of family, monthly income, menopausal status, the feeling of life. self-reported health states, economic satisfaction). 4. The score of climacteric symptoms complained is significantly different according to the stress of life events (p<0.051, Especially, the difference is the widest in psychological symptoms according to the factor of 'couple. marrital life' among stressful life events. In Summary, climacteric symptoms complained by middle-aged women are related to the amount of the stress of life events. Whether life events are positive of negative is not important. Yet. climacteric symptoms and stressful life events are deeply related to general characteristics. so we can not insist strongly that one be directly related to the other.

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