• Title, Summary, Keyword: ${\beta}-cyclodextrin$

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Cholesterol Contents of Pork Fed Dietary β-Cyclodextrin (BCD를 섭취한 돼지의 부위별 콜레스테롤 함량)

  • Kang, Hwan-Ku;Park, Byung-Sung
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.36 no.2
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    • pp.180-185
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    • 2007
  • This study demonstrates that pork cholesterol levels are reduced in fattening stage swine fed $\beta-cyclodextrin({\beta}-cyclodextrin)$. The study subjects were 120 swine fed their respective chow diets containing 0, 5, 7, or 10% $\beta$-cyclodextrin for 35 consecutive days. Plasma total lipids, triglyceride and total cholesterol of the $\beta$-cyclodextrin treated group were significantly lower than those of the control group (p<0.05). The levels of plasma lipid were significantly decreased by 63.22 mg, 73.98 mg, and 82.12 mg in the fattening swine group fed $\beta$-cyclodextrin at 5%, 7%, and 10%, respectively, compared to those in the control group (p<0.05). When 5, 7, and 10% $\beta$-cyclodextrin was administered to fattening swine, the triacylglyceride levels were decreased by 56.24 mg, 55.48 mg, and 60.02 mg, and total cholesterol concentration was reduced by 25.05 mg, 27.17 mg, and 30.19 mg, respectively, compared to those in the control group (p<0.05). Excretion of total steroid significantly (p<0.05) increased with the increasing amount of $\beta$-cyclodextrin supplementation. The cholesterol levels of swine back fat, belly, loin, and ham were significantly decreased with increasing $\beta$-cyclodextrin supplementation (p<0.05). The pork cholesterol was significantly (p<0.05) reduced by 15.31% in the $\beta$-cyclodextrin treated group, compared to that of the control group. These results suggest that feeding $\beta$-cyclodextrin to fattening swine may produce novel functional pork with low cholesterol levels.

Recycling of $\beta$-Cyclodextrin Used for Cholesterol Removal from Egg Yolk (난황의 콜레스테롤 제거에 사용한 $\beta$-Cyclodextrin의 재활용)

  • 유익종;최성유;박우문;전기홍
    • Food Science of Animal Resources
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    • v.20 no.1
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    • pp.30-35
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    • 2000
  • The method used to remove cholesterol from egg by using $beta$-cyclodextrin was relatively stable and efficient. The aim of this study was to cost down by recycling $\beta$-cyclodextrin used to remove cholesterol from egg yolk because $\beta$-cyclodextrin was expensive. The solvents used to separate $\beta$-cyclodextrin from $\beta$-cyclodextrin complex containing egg yolk cholesterol were butanol, chloroform, ether, hexane, methanol, 2-propanol and their mixture. The ratio of solvent and complex varied from 2 : 1 to 10 : 1. The condition of mixing time and temperature varied from 30 to 60$^{\circ}C$ and from 10 minutes to 3 hours to remove cholesterol from $\beta$-cyclodextrin complex. When the ratio of choloroform and methanol was 1 : 1, the removal efficiency of cholesterol was 98.8%. The efficiency of cholesterol removal was improved when the ratio of solvent : complex increased to 4 : 1. When mixing time and temperature was up to for 1hr, at 50$^{\circ}C$ respectively, the efficiency of cholesterol removal improved to 99%. It concluded that the efficiency of cholesterol removal of 50% renewed one contained $\beta$-cyclodextrin were 81.1% while the cholesterol removal efficiency of 100% renewed $\beta$-cyclodextrin was 24% if cholesterol removal efficiency of new $\beta$-cyclodextrin were 100%.

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Polymerization of Acrylonitrile Initiated by Ce(IV)-$\beta$-Cyclodextrin Redox System (Ce(IV)-$\beta$-시클로텍스트린 개시계에 의한 아크릴로니트릴의 중합)

  • 마석일;이의정
    • Textile Science and Engineering
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    • v.26 no.4
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    • pp.27-32
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    • 1989
  • In order to obtain polyacrylonitrile having $\beta$-cyclodextrin ring as an end group, acrylonitrile was polymerized in aqueous solution of ceric ammonium nitrate and $\beta$-cyclodextrin has been carried out. From the kinetic results, it was concluded that Ce(IV) formed a complex with $\beta$-cyclodextrin and the polymerization was initiated by a radical species produced on $\beta$-cyclodextrin by disproportionation of redox pair of Ce(IV)-$\beta$-cyclodextrin complex.

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Production Enhancement of Benzophenanthridine alkaloids in the Suspension Cultures of California poppy using Cyclodextrin (양귀비 세포 현탁배양계에서 Cyclodextrin을 이용한 Benzophenanthridine alkaloids의 생산성 증대)

  • 박세춘;조규헌
    • KSBB Journal
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    • v.11 no.4
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    • pp.411-419
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    • 1996
  • In this research, an extractive production system for alkaloids, where production and some degree of separation occur simultaneously, was developed in a way that the fast removal of alkaloid produced from the suspension cultures was done by capturing alkaloid with cyclodextrins. The alkaloid production was substantially enhanced up to 40 fold when the solid cultures of E. califonica cells treated with ${\beta}$-cyclodextrin compared to the control. The enhancement of alkaloid production was also observed in the suspension cultures. Interestingly, the production pattern seemed to change when the cultures were treated with ${\beta}$-cyclodextrin so that the major part of the alkaloids in the treated cultures was present in the medium, while the non-treated cultures produced the alkaloids intracellularly. ${\beta}$-cyclodextrin was the most effective one in terms of the alkaloid production among the cyclodextrilns(${\alpha}$-cylodextrin, ${\beta}$-cyclodextrin and ${\gamma}$-cyclodextrin) tested in the suspension cultures. ${\beta}$-cyclodextrin showed no adverse effect on the cell growth. The most effective concentration of ${\beta}$-cyclodextrin was observed around 1.5% (w/v) in the suspension cultures. The formation of the inclusion complex of the alkaloids with ${\beta}$-cyclodextrin in the suspension cultures was confirmed by detecting the shift of UV absorbance from 274 nm to 282 nm with a UV spectrophotometer.

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Interaction of Beta-cyclodextrin with Some Pharmaceuticals (Beta-cyclodextrin과 의약품(醫藥品)과의 상호작용(相互作用))

  • Kim, Shin-Keun
    • Journal of Pharmaceutical Investigation
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    • v.4 no.1_2
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    • pp.13-18
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    • 1974
  • Data are present for the interaction of beta-cyclodextrin with 7 pharmaceuticals in aqueous solution. By means of the solubility method of analysis, definite interaction were found to occur with all the compounds tested. The amount of these pharmaceuticals in equilibrium with their respective solid phase increased progressively with beta-cyclodextrin. A concentration of 1.5 g of beta-cyclodextrin per 100 ml of water increased the solubility of most compounds tested (except one) by 15-120%. Hydrolysis in alkali solution of chrolothiazide was retarded in the presence of beta-cyclodextrin.

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[ ${\beta}-cyclodextrin$ ] inclusion properties with guest molecules using hetero-bi-functional reactive dye

  • Kim, Byung-Soon;Kim, Young-Sung;Son, Young-A
    • Textile Coloration and Finishing
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    • v.19 no.2
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    • pp.32-35
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    • 2007
  • Cyclodextrin is a cyclic oligosaccharid material which shows an ability to incorporate organic guest molecules inside their cavity area. Thus, this ${\beta}-cyclodextrin$ treatment on fiber substrates may provide the changed surface characteristics of the substrates such as solubility, chemical reactivity and spectral property. In this context, the aim of this present work is to make a bridge connection using hetero-bi-functional reactive dye between fiber substrates and ${\beta}-cyclodextrin$. In addition, the corresponding Berberine inclusion behaviors into the inner cavity of ${\beta}-cyclodextrin$ was examined. The %exhaustion of Berberine inclusion as a guest molecule within the ${\beta}-cyclodextrin$ was measured using UV-Vis spectrophotometer. The findings showed that the %exhaustion of Berberine inclusion increased with increasing the prepared dye bridge compound and ${\beta}-cyclodextrin$ host material.

Hemolysis and Mutagenicity test on the Inclusion Complex of Omeprazol with $\beta$-Cyclodextrinand Hydroxypropyl$\beta$ Cyclodextrin (Omeprazol과 $\beta$-Cyclodextrin, Hydroxypropyl-$\beta$-Cyclodextrin의 포접화합물에 대한 적혈구 손상 및 변이원성시험 연구)

  • 김봉희;이계주
    • Journal of Food Hygiene and Safety
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    • v.10 no.1
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    • pp.29-32
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    • 1995
  • Inclusion complex of omeprazol with $\beta$-Cyclodextrin and Hydroxypropyl-$\beta$-Cyclodextrin were prepared by coprecipitation and freeze-drying method respectively. Effects of these inclusion complex on RBCs were monitored with a spectrophotometer by the method of Kahan et al. and the mutagenic activity based on the Ames plate incorporation test in the presence and absence of liver microsomal enzyme(S9 fraction) using Salmonella typhimurium TA98 and TA100. The RBCs hemolysis and mutagenic activity of these complex were not detected.

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Effect of Water-Activity Depressor on the Enzymatic Synthesis of Maltosyl-$\beta$-Cyclodextrin through the Reverse Reaction of Pullulanase (Water-Activity Depressor가 Pullulanase의 역반응에 의한 Maltosyl-$\beta$-Cyclodextrin의 합성에 미치는 영향)

  • 이용현;한일근
    • Microbiology and Biotechnology Letters
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    • v.20 no.4
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    • pp.422-429
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    • 1992
  • The effect of various water-activity depressors, such as pol yo Is, sugars, and polymers, on the conversion yields of the enzymatic synthesis of maltosyl-$\beta$-cyclodextrin from $\beta$-cyc1odextrin and maltose through reverse reaction of pullulanase was investigated. PEG 6000 of concentration of 10% (w/w) was found to be the most acceptable water-activity depressor resulting for increment of conversion yield from 43.0% to 55.9%, corresponding maltosyl-$\beta$-cyc1odextrin concentration of 3.02 g/100 ml H20. Water activity was changed from initial 0.966 to 0.914 upon addition of 20% (w/w) of PEG 6000. The conversion yields were inversely proportional to the water activities, and the increased conversion yield was caused by water activity depression which inhibited the hydrolysis reaction of maltosyl-$\beta$-CD to maltose and $\beta$-cyc1odextrin. The changes of enthalpy ($\Delta$H), entropy ($\Delta$S), and Gibbs free energy ($\Delta$G) were calculated to be 36.788 kJ/mole, 0.067 kJ/mole K. and 14.433 kJ/mole, respectively. The synthesis of maltosyl-$\beta$-CD could be increased substantially by the intermittent feeding of $\beta$-cyclodextrin. PEG 6000 could be separated effectively from reaction mixture using ultrafiltration membrane for reutilization.

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Perfumed Finishing of Cotton Fabric by Treatment of ${\beta}$-cyclodextrin and Crosslinking Agent (${\beta}$-cyclodextrin 및 가교제 처리에 의한 면직물의 방향가공)

  • Huh, Jong-Tea;Lee, Kyung-Ju;Pak, Pyong-Ki;Chung, Yong-Sik
    • Textile Science and Engineering
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    • v.44 no.2
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    • pp.90-96
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    • 2007
  • [ ${\beta}$ ]-cyclodextrin having an inclusion property was applied to perfumed finishing of textile goods. ${\beta}$-cyclodextrin was treated on the cotton fabric with polycarboxylic acid such as citric acid and butanetetracarboxylic acid. The fact that ${\beta}$-cyclodextrin is covalently bound to cotton fabric with butanetetracarboxylic acid was confirmed by IR spectrum, TGA thermogram, and dyeing with basic dye. In case of citric acid, the result was not satisfactory, which was supported by laundering durability experiment. When cotton fabric treated with crosslinking agent and ${\beta}$-cyclodextrin was compared with cotton fabric treated with only crosslinking agent, they gave similar values in dry wrinkle recovery angle. Perfumed finishing with ${\beta}$-cyclodextrin including perfume was possible.

Production Enhancement of Menthol in Suspension Cultures of Peppermint Using Cyclodextrin (Peppermint 세포 현탁배양에서 Cyclodextrin을 이용한 Menthol의 생산성 증대)

  • 조규헌;임철호;박세춘;신명근
    • KSBB Journal
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    • v.13 no.1
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    • pp.26-30
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    • 1998
  • The suspension cultures of Mentha piperita produce menthol which has very low solubility in water due to its hydrophobicity. This can be considered as a factor for its low production in the suspension suspension cultures. Cyclodextrin has the hydrophobic cavity inside the molecule in which menthol can be captured and allow to form a stable complex. The suspension culture of Mentha piperita showed 70% higher production enhancement in the medium containing 1.5%(w/v) $\beta$-cyclodextrin than the control. $\beta$-cyclodextrin had no adverse effect on the cell growth and showed the best result among $\alpha$-, $\beta$- and $\gamma$-cyclodextrins tested in terms of menthol production. We demonstrated that $\beta$-cyclodextrin can be used to enhance the production of menthol in the suspension cultures by capturing hydrophobic menthol into the cavity of cyclodextrin molecules.

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