- Volume 14 Issue 2
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Nutrikinetic study of fermented soybean paste (Cheonggukjang) isoflavones according to the Sasang typology
- Kim, Min Jung (Research Division of Food Functionality, Korea Food Research Institute) ;
- Lee, Da-Hye (Research Division of Food Functionality, Korea Food Research Institute) ;
- Ahn, Jiyun (Research Division of Food Functionality, Korea Food Research Institute) ;
- Jang, Young-Jin (Research Division of Food Functionality, Korea Food Research Institute) ;
- Ha, Tae-Youl (Research Division of Food Functionality, Korea Food Research Institute) ;
- Do, Eunju (Clinical Trial Convergence Commercialization Team, Korea Medicine Industry Support Center) ;
- Jung, Chang Hwa (Research Division of Food Functionality, Korea Food Research Institute)
- Received : 2018.10.30
- Accepted : 2019.11.07
- Published : 2020.04.01
BACKGROUND/OBJECTIVES: In Oriental medicine, certain foods may be beneficial or detrimental based on an individual's constitution; however, the scientific basis for this theory is insufficient. The purpose of this study was to investigate the effect of body constitution, based on the Sasang type of Korean traditional medical classification system, on the bioavailability of soy isoflavones of Cheonggukjang, a quick-fermented soybean paste. SUBJECTS/METHODS: A pilot study was conducted on 48 healthy Korean men to evaluate the bioavailability of isoflavone after ingestion of food based on constitution types classified by the Sasang typology. The participants were classified into the Taeeumin (TE; n = 15), Soyangin (SY; n = 15), and Soeumin (SE; n = 18) groups. Each participant ingested 50 g of Cheonggukjang per 60 kg body weight. Thereafter, blood was collected, and the soy isoflavone metabolites were analyzed by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Ntrikinetic analysis of individual isoflavone-derived metabolites was performed. RESULTS: Our nutrikinetic analysis identified 21 metabolites derived from isoflavones in the blood samples from 48 healthy Korean men (age range, 21-29 years). Significant differences were observed in the time to maximum concentration (Tmax) and elimination half-life (t1/2) for nine metabolites among the three groups. The Tmax and t1/2 of the nine metabolites were higher in the SE group than in the other groups. Moreover, the absorption rates, as determined by the area under the plasma-level curve (AUC) values of intact isoflavone, were 5.3 and 9.4 times higher in the TE group than in the SY and SE groups, respectively. Additionally, the highest AUC values for phase I and II metabolites were observed in the TE group. CONCLUSIONS: These findings indicate that isoflavone bioavailability, following Cheonggukjang insgestion, is high in individuals with the TE constitution, and relatively lower in those with the SE and SY constitutions.
Supported by : Korea Food Research Institute (KFRI)
- Yoo J, Lee E, Kim C, Lee J, Lixing L. Sasang constitutional medicine and traditional Chinese medicine: a comparative overview. Evid Based Complement Alternat Med 2012;2012:980807.
- Kim JY, Pham DD. Sasang constitutional medicine as a holistic tailored medicine. Evid Based Complement Alternat Med 2009;6 Suppl 1:11-9.
- Shin S, Kim YH, Hwang MW. Diagnosis and treatment principle in Sasang medicine: original symptom. Integr Med Res 2016;5:99-104. https://doi.org/10.1016/j.imr.2016.03.005
- Lee J, Jung Y, Yoo J, Lee E, Koh B. Perspective of the human body in sasang constitutional medicine. Evid Based Complement Alternat Med 2009;6 Suppl 1:31-41.
- Kim JY, Kim CW, Koh BH, Song IB. Justification and usage of food classification according to body constitution. J Sasang Const Med 1995;7:263-79.
- Lee CH. Health concept in traditional Korean diet, in therapeutic use of foods in East Asia. Korean Korean Am Stud Bull 1998;9:8-18.
- Lee CH. Harmonization of eastern and western health knowledge; nutrigenetics and Sasang typology. Food Sci Technol Res 2007;13:89-95. https://doi.org/10.3136/fstr.13.89
- Lee J, Lee J, Lee E, Yoo J, Kim Y, Koh B. The Sasang constitutional types can act as a risk factor for hypertension. Clin Exp Hypertens 2011;33:525-32. https://doi.org/10.3109/10641963.2011.561901
- Cho NH, Kim JY, Kim SS, Lee SK, Shin C. Predicting type 2 diabetes using Sasang constitutional medicine. J Diabetes Investig 2014;5:525-32. https://doi.org/10.1111/jdi.12189
- Lee SK, Yoon DW, Yi H, Lee SW, Kim JY, Shin C. Tae-eum type as an independent risk factor for obstructive sleep apnea. Evid Based Complement Alternat Med 2013;2013:910382.
- Choi K, Lee J, Yoo J, Lee E, Koh B, Lee J. Sasang constitutional types can act as a risk factor for insulin resistance. Diabetes Res Clin Pract 2011;91:e57-60. https://doi.org/10.1016/j.diabres.2010.11.017
- Lee SK, Yoon DW, Lee SW, Kim JY, Kim JK, Shin C. Non-alcoholic fatty liver disease among sasang constitutional types: a populationbased study in Korea. BMC Complement Altern Med 2015;15:399. https://doi.org/10.1186/s12906-015-0925-8
- Lee TG, Koh B, Lee S. Sasang constitution as a risk factor for diabetes mellitus: a cross-sectional study. Evid Based Complement Alternat Med 2009;6 Suppl 1:99-103.
- Moon HJ, Jung SJ. Nursing approach of four constitutional theory. J Korea Community Health Nurs Acad Soc 1996;10:139-54.
- Kim YY, Choue R, Song IB, Lee EJ. The clinical effect of Sasang constitutional diets for the hypercholesterolemic patients. Korean J Nutr 2000;33:824-32.
- Yang M, Lee HS, Hwang MW, Jin M. Effects of Korean red ginseng (Panax Ginseng Meyer) on bisphenol A exposure and gynecologic complaints: single blind, randomized clinical trial of efficacy and safety. BMC Complement Altern Med 2014;14:265. https://doi.org/10.1186/1472-6882-14-265
- Choi JH, Pichiah PB, Kim MJ, Cha YS. Cheonggukjang, a soybean paste fermented with B. licheniformis-67 prevents weight gain and improves glycemic control in high fat diet induced obese mice. J Clin Biochem Nutr 2016;59:31-8. https://doi.org/10.3164/jcbn.15-30
- Kang SJ, Seo JY, Cho KM, Lee CK, Kim JH, Kim JS. Antioxidant and neuroprotective effects of Doenjang prepared with Rhizopus, Pichia, and Bacillus. Prev Nutr Food Sci 2016;21:221-6. https://doi.org/10.3746/pnf.2016.21.3.221
- Wu WJ, Lee HY, Lee GH, Chae HJ, Ahn BY. The antiosteoporotic effects of Cheonggukjang containing vitamin k2 (menaquinone-7) in ovariectomized rats. J Med Food 2014;17:1298-305. https://doi.org/10.1089/jmf.2013.3095
- Lee SY, Park SL, Hwang JT, Yi SH, Nam YD, Lim SI. Antidiabetic effect of Morinda citrifolia (Noni) fermented by Cheonggukjang in KK-A(y) diabetic mice. Evid Based Complement Alternat Med 2012;2012:163280.
- Lee DH, Kim MJ, Ahn J, Lee SH, Lee H, Kim JH, Park SH, Jang YJ, Ha TY, Jung CH. Nutrikinetics of isoflavone metabolites after fermented soybean product (Cheonggukjang) ingestion in ovariectomized mice. Mol Nutr Food Res 2017;61.
- Kim MJ, Lee DH, Ahn J, Ha TY, Jang YJ, Do E, Jung CH. A pilot study on characteristics of metabolomics and lipidomics according to Sasang constitution. Evid Based Complement Alternat Med 2018;2018:9214960.
- Lee SJ, Park SH, Cloninger CR, Kim YH, Hwang M, Chae H. Biopsychological traits of Sasang typology based on Sasang personality questionnaire and body mass index. BMC Complement Altern Med 2014;14:315. https://doi.org/10.1186/1472-6882-14-315
- Kim SH, Lee Y, Koh BH, Jang E. Assessing the diagnostic accuracy of the questionnaire for Sasang constitutional classification II (QSCC II): a systematic review. Eur J Integr Med 2013;5:393-8. https://doi.org/10.1016/j.eujim.2013.05.003
- Kim EJ, Choue R, Song IB. The food classification in Sasang constitution and effects of Tae-um constitutional diet on the blood biochemical parameters and health status. Korean J Nutr 1999;32:827-37.
- Lee DH, Kim MJ, Song EJ, Kim JH, Ahn J, Nam YD, Jang YJ, Ha TY, Jung CH. Nutrikinetic study of genistein metabolites in ovariectomized mice. PLoS One 2017;12:e0186320. https://doi.org/10.1371/journal.pone.0186320
- Coll AP, Farooqi IS, O'Rahilly S. The hormonal control of food intake. Cell 2007;129:251-62. https://doi.org/10.1016/j.cell.2007.04.001
- Shin D, Jeong D. Korean traditional fermented soybean products: Jang. J Ethn Food 2015;2:2-7. https://doi.org/10.1016/j.jef.2015.02.002
- Lee BH, Kwon KB, Han JH, Ryu DG. Bibliographical study on the constitutional foods in Korean medicine. Korean J Orient Physiol Pathol 2009;23:1207-20.
- Atkinson C, Frankenfeld CL, Lampe JW. Gut bacterial metabolism of the soy isoflavone daidzein: exploring the relevance to human health. Exp Biol Med (Maywood) 2005;230:155-70. https://doi.org/10.1177/153537020523000302