Sericin and 4-hexylresorcinol combination ointment accelerates wound healing in the diabetic burn wound model

  • Kang, Yei-Jin (Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University) ;
  • Jo, You-Young (Sericultural and Apicultural Materials Division, National Institute of Agricultural Sciences, RDA) ;
  • Kweon, HaeYong (Sericultural and Apicultural Materials Division, National Institute of Agricultural Sciences, RDA) ;
  • Kim, Seong-Gon (Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University)
  • Received : 2020.02.10
  • Accepted : 2020.02.27
  • Published : 2020.03.31


Sericin has been used for the treatment of burn wound. The purpose of this study was to compare the wound healing between sericin plus 4-hexylresorcinol (4HR) ointment (SE+4HR) and base only ointment. Total 12 mice were included in this study. SE+4HR group showed significantly smaller wound size than base only group at 3 wk (P<0.05). Surface temperature was higher in SE+4HR group. In conclusion, SE+4HR group showed better wound healing than base only group.


Supported by : Rural Development Administration


  1. Ahn J, Kim SG, Kim MK, Kim DW, Lee JH, Seok H, et al. (2016) Topical delivery of 4-hexylresorcinol promotes wound healing via tumor necrosis factor-${\alpha}$ suppression. Burns 42(7), 1534-1541.
  2. Alavi A, Sibbald RG, Mayer D, Goodman L, Botros M, Armstrong DG, et al. (2014) Diabetic foot ulcers: Part I. Pathophysiology and prevention. J Am Acad Dermatol 70(1), 1.e1-18.
  3. Bairagi A, Griffin B, Tyack Z, Vagenas D, McPhail SM, Kimble R (2019) Comparative effectiveness of Biobrane(R), RECELL(R) Autologous skin cell suspension and silver dressings in partial thickness paediatric burns: BRACS randomised trial protocol. Burns Trauma 7, 33.
  4. Chen Z, Klein T, Murray RZ, Crawford R, Chang J, Wu C, et al. (2016) Osteoimmunomodulation for the development of advanced bone biomaterials. Materials Today 19, 304-321.
  5. Dhandha MM (2020) Skin Infections and outpatient burn management: skin Infections in patients with diabetes. FP Essent 489, 21-26.
  6. Jeffcoate WJ, Harding KG (2003) Diabetic foot ulcers. Lancet 361(9368), 1545-1551.
  7. Jo YY, Kim DW, Choi JY, Kim SG (2019) 4-Hexylresorcinol and silk sericin increase the expression of vascular endothelial growth factor via different pathways. Sci Rep 9, 3448.
  8. Jo YY, Kweon H, Kim DW, Baek K, Kim MK, Kim SG, et al. (2017) Bone regeneration is associated with the concentration of tumour necrosis factor-${\alpha}$ induced by sericin released from a silk mat. Sci Rep 7, 15589.
  9. Joob B, Wiwanitkit V (2013) Silk sericin and burn wound. Arch Dermatol Res 305(6), 555.
  10. Kamalathevan P, Ooi PS, Loo YL (2018) Silk-based biomaterials in cutaneous wound healing: a systematic review. Adv Skin Wound Care 31(12), 565-573.
  11. Karahaliloglu Z, Kilicay E, Denkbas EB (2017) Antibacterial chitosan/silk sericin 3D porous scaffolds as a wound dressing material. Artif Cells Nanomed Biotechnol 45(6), 1-14.
  12. Kath MA, Shupp JW, Matt SE, Shaw JD, Johnson LS, Pavlovich AR, et al. (2011) Incidence of methemoglobinemia in patients receiving cerium nitrate and silver sulfadiazine for the treatment of burn wounds: a burn center's experience. Wound Rep Regen 19(2), 201-204.
  13. Kim MK, Yoon CS, Kim SG, Park YW, Lee SS, Lee SK (2019) Effects of 4-hexylresorcinol on protein expressions in RAW264.7 cells as determined by immunoprecipitation high performance liquid chromatography. Sci Rep 9, 3379.
  14. Lee WY, Um IC, Kim MK, Kwon KJ, Kim SG, Park YW (2014) Effectiveness of woven silk dressing materials on full-skin thickness burn wounds in rat model. Maxillofac Plast Reconstr Surg 36(6), 280-284.
  15. Panilaitis B, Altman GH, Chen J, Jin HJ, Karageorgiou V, Kaplan DL (2003) Macrophage responses to silk. Biomaterials 24(18), 3079-3085.
  16. Spiller KL, Nassiri S, Witherel CE, Anfang RR, Ng J, Nakazawa KR, et al. (2015) Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds. Biomaterials 37, 194-207.
  17. Sterling JP (2014) Silver-resistance, allergy, and blue skin: truth or urban legend? Burns 40 Suppl 1, S19-S23.
  18. Tattersall GJ (2016) Infrared thermography: A non-invasive window into thermal physiology. Comp Biochem Physiol A Mol Integr Physiol 202, 78-98.