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Anti-ecotoxicological Glycoprotein Isolated from Ulmus davidiana Nakai Inhibits Fecal Malodor and Promotes Feed Efficiency in Mice

환경 독성을 억제하는 느릅 당단백질이 마우스의 분뇨 악취저감 및 사료 효율에 미치는 영향

  • Kim, Do-Wan (Department of Pharmaceutical Engineering, Daegu Haany University) ;
  • Park, Moon-Ki (Department of Pharmaceutical Engineering, Daegu Haany University) ;
  • Lee, Sei-Jung (Department of Pharmaceutical Engineering, Daegu Haany University)
  • 김도완 (대구한의대학교 제약공학과) ;
  • 박문기 (대구한의대학교 제약공학과) ;
  • 이세중 (대구한의대학교 제약공학과)
  • Received : 2019.12.13
  • Accepted : 2020.02.04
  • Published : 2020.03.31

Abstract

Ulmus davidiana Nakai (UDN) has been traditionally used as a herbal medicine in Korea. In the present study, we investigated the anti-ecotoxic potential of a 116 kDa glycoprotein isolated from UDN (UDN glycoprot ein) in regulating fecal malodor and feed efficiency in mice. We found that UDN glycoprotein (200 μg/ml) has an inhibitory effect on the cell death induced by an ecotoxicological endocrine disrupting chemical, bisphenol A, in colon epithelial HT-29 cells. UDN glycoprotein did not show significant differences regarding the weight of ecotoxicity-related organs (liver, heart, kidneys, and spleen) and the levels of serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, and lactate dehydrogenase in mice for 2 weeks, compared to the control. Additionally, UDN glycoprotein reduced the levels of hydrogen sulfide and ammonia as markers of fecal malodor in mice. Interestingly, UDN glycoprotein can improve the mouse feed efficiency. In conclusion, our data indicate that anti-ecotoxicological UDN glycoprotein has the ability to increase the feed efficiency and reduce the fecal malodor by maintaining the viability of colonic epithelial cells in mice.

Acknowledgement

Supported by : 한국연구재단

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