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Equilibrium, Isotherm, Kinetic and Thermodynamic Studies for Adsorption of 7-Epi-10-deacetylpaclitaxel from Taxus chinensis on Sylopute

실로퓨트에 의한 Taxus chinensis 유래 7-에피-10-디아세틸파클리탁셀의 흡착에 대한 평형, 등온흡착식, 동역학 및 열역학적 특성

  • Park, Sae-Hoon (Department of Chemical Engineering, Kongju National University) ;
  • Kim, Jin-Hyun (Department of Chemical Engineering, Kongju National University)
  • 박세훈 (공주대학교 화학공학부) ;
  • 김진현 (공주대학교 화학공학부)

Abstract

In batch experiments, the adsorption of 7-epi-10-deacetylpaclitaxel was studied using Sylopute. Experimental equilibrium data were applied to Langmuir, Freundlich, Temkin and Dubinin-Radushkevich isotherm models. Among the four isotherm models tested, the Langmuir isotherm model gave the highest accuracy. The adsorption capacity was found to decrease with increases in temperature and the adsorption of 7-epi-10-deacetylpaclitaxel onto Sylopute was a favorable physical process. Adsorption kinetic data agreed very well with the pseudo-second-order kinetic model, while boundary layer diffusion and intraparticle diffusion did not play a key role in the adsorption process. The process of 7-epi-10-deacetylpaclitaxel adsorption onto Sylopute was exothermic and nonspontaneous. Also, the adsorption isosteric heat was independent of surface loading indicating an energetically homogeneous adsorbent.