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A Case of Angioimmunoblastic T-cell Lymphoma Involving the Ipsilateral Parotid and Lateral Neck

동측 이하선과 측경부에 발생한 혈관면역모세포 T세포 림프종 1예

  • Hong, Seok Jung (Department of Otolaryngology-Head and Neck Surgery, Veterans Health Service Medical Center) ;
  • Lee, Mi Ji (Department of Pathology, Veterans Health Service Medical Center) ;
  • Kim, Seung Woo (Department of Otolaryngology-Head and Neck Surgery, Veterans Health Service Medical Center)
  • 홍석정 (중앙보훈병원 이비인후과) ;
  • 이미지 (중앙보훈병원 병리과) ;
  • 김승우 (중앙보훈병원 이비인후과)
  • Received : 2019.03.05
  • Accepted : 2019.05.10
  • Published : 2019.05.31

Abstract

Angioimmunoblastic T-cell lymphoma (AITL) is a rare subtype of malignant lymphoma (ML), accounting for only 1 to 2% of all non-Hodgkin's lymphoma (NHL). Although ML of the parotid gland is rare, the majority are B-cell types. The AITL occurring synchronously in the parotid gland and lateral neck has not been reported earlier. It is classified as a high-grade malignancy with aggressive clinical features, and the prognosis is worse than any other type of NHL. We recently encountered a 72-year-old man with multiple mass on the ipsilateral parotid tail and lateral neck, and he was finally diagnosed as AITL. We report the unique and rare disease entity with a brief literature review.

References

  1. Baek JY, Park SR, Choi IS, Kim SI, Kim DW, Kim JH, et al. Angioimmunoblastic T-cell lymphoma: Clinical characteristics and treatment outcomes. Korean J Hematol. 2005;40:8-14. https://doi.org/10.5045/kjh.2005.40.1.8
  2. Feinstein AJ, Ciarleglio MM, Cong X, Otremba MD, Judson BL. Parotid gland lymphoma: Prognostic analysis of 2140 patients. Laryngoscope. 2013;123:1199-1203. https://doi.org/10.1002/lary.23901
  3. Argyris PP, Koutlas IG, Cooley S, Yohe SL, Bhakta K, Gopalakrishnan R. Angioimmunoblastic T-cell lymphoma of the oral cavity presenting as gingival mass: Report of the histopathologic and molecular characteristics of an unusual case featuring clonal T-cell receptor ${\gamma}$ gene rearrangement by polymerase chain reaction. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118:e198-204. https://doi.org/10.1016/j.oooo.2014.07.006
  4. Picard A, Cardinne C, Denoux Y, Wagner I, Chabolle F, Bach CA. Extranodal lymphoma of the head and neck: A 67-case series. Eur Ann Otorhinolaryngol Head Neck Dis. 2015;132:71-75. https://doi.org/10.1016/j.anorl.2014.07.005
  5. Jayarajan J, Azad A. A rare cause of bilateral parotid enlargement: Angioimmunoblastic T-cell lymphoma. ANZ J Surg. 2009;79:769.
  6. Jaffe ES. Lymphoid lesions of the head and neck: A model of lymphocyte homing and lymphomagenesis. Mod Pathol. 2002;15:255-263. https://doi.org/10.1038/modpathol.3880521
  7. Yanagawa N, Osakabe M, Furuse H, Maeda K, Tamura G. Peripheral T-cell lymphoma arising from an intraglandular lymph node in the parotid gland: A case report and literature review. Pathol Int. 2012;62:60-64. https://doi.org/10.1111/j.1440-1827.2011.02747.x
  8. Federico M, Rudiger T, Bellei M, Nathwani BN, Luminari S, Coiffier B, et al. Clinicopathologic characteristics of angioimmunoblastic T-cell lymphoma: Analysis of the international peripheral T-cell lymphoma project. J Clin Oncol. 2013;31:240-246.
  9. Zhu L, Wang P, Yang J, Yu Q. Non-Hodgkin lymphoma involving the parotid gland: CT and MR imaging findings. Dentomaxillofac Radiol. 2013;42:20130046. https://doi.org/10.1259/dmfr.20130046
  10. Sah DJ, Kwak SG, Kim CD, Kim SW. Unilateral synchronous intra-and extra-parotid Warthin's tumor, presenting as a similar pattern of cervical metastasis from parotid cancer: A case report. Korean J Head Neck Oncol. 2013;29:11-13.