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Fabrication and Evaluation of Polyelectrolyte Complexes of Dextran Derivatives for Drug Coating of Coronary Stents

  • Jang, Eun-Jae (Biopharmaceutical Research Center) ;
  • Lee, So-Youn (The Cardiovascular Convergence Research Center of Chonnam National University, Hospital Designated by Ministry of Health and Welfare) ;
  • Bae, In-Ho (The Cardiovascular Convergence Research Center of Chonnam National University, Hospital Designated by Ministry of Health and Welfare) ;
  • Park, Dae Sung (The Cardiovascular Convergence Research Center of Chonnam National University, Hospital Designated by Ministry of Health and Welfare) ;
  • Jeong, Myung Ho (Department of Cardiology, Chonnam National University Hospital) ;
  • Park, Jun-Kyu (CGBio Co. Ltd)
  • Received : 2019.07.19
  • Accepted : 2019.08.20
  • Published : 2019.10.10

Abstract

The aim of this study was to fabricate a dextran polyelectrolyte multi-layer on a bare metal stent (BMS) and to evaluate bio-physical properties of the layer. Diethylaminoethyl-dextran (DEAE-D) as a polycation and dextran sulfate (DS) as a polyanion were successively coated on the bare metal stent by a well-known layer-by-layer procedure. The morphology of the stent surface and its cell adhesion were studied after each coating step by scanning electron microscopy. The stent showed more blotched and slightly rougher morphology after dextran-DS coating. The contact angle of the DEAE-DS group ($39.5{\pm}0.15^{\circ}$) was significantly higher than that of the BMS group ($45.16{\pm}0.08^{\circ}$), indicating the improvement of hydrophilic. The SMC proliferation inhibition in the DEAE-DS-coated stent group ($20.9{\pm}0.04%$) was stronger than that in the control group ($21.7{\pm}0.10%$ in DS-coated group only). The DEAE-DS coating is desired for stent coating materials with biocompatibility and anti-restenosis effect.

Acknowledgement

Grant : Regional Specialized Industry Development Program

Supported by : Ministry of Health & Welfare, Korea Institute for Advancement of Technology (KIAT), Jellanamdo

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