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Anti-inflammatory activity of Eurya persicifolia Gagnep. extract in Propionibacterium acnes-induced inflammatory signaling by regulation of NF-κB activity

Propionibacterium acnes에 의한 염증반응에서 Eurya persicifolia Gagnep. 추출물의 억제효과

  • Shin, Jin Hak (Department of Molecular Bioscience, College of Biomedical Science, Institute of Bioscience & Biotechnology, Kangwon National University) ;
  • Seo, Su Ryeon (Department of Molecular Bioscience, College of Biomedical Science, Institute of Bioscience & Biotechnology, Kangwon National University)
  • 신진학 (강원대학교 분자생명과학과) ;
  • 서수련 (강원대학교 분자생명과학과)
  • Received : 2019.07.31
  • Accepted : 2019.08.14
  • Published : 2019.09.30

Abstract

Acne is a chronic inflammatory disease outbreak in the sebaceous glands within the hair follicle. The proliferation of Propionibacterium acnes (P. acnes) causes monocytes to stimulate secretion of inflammatory cytokines. A number of studies proposed the inhibitory effects of P. acnes-mediated inflammation by several natural extracts. However, studies on the effect of Eurya persicifolia Gagnep. (E. persicifolia) extracts on the inflammatory responses by P. acnes have not been explored yet. In this study, we investigated the anti-inflammatory effect of E. persicifolia extract in the inflammatory reactions induced by P. acnes. We found that E. persicifolia extract successfully diminished the expression levels of inflammatory mediators such as IL-$1{\beta}$, IL-6, TNF-${\alpha}$, and iNOS in P. acnes-activated mouse macrophage RAW 264.7 cells. We found that the immunosuppressive effect of E. persicifolia extract in the P. acnes-activated inflammatory signaling is mediated by the regulation of NF-${\kappa}B$ transcriptional activation, which is a key regulator of inflammatory cytokine expression. Our results suggest that E. persicifolia extract held potentials for the treatment of P. acnes by suppressing NF-${\kappa}B$ signaling pathways.

Keywords

E. persicifolia Gagnep.;Propionibacterium acnes;acne;inflammation;pro-inflammatory cytokine

Acknowledgement

Supported by : 강원대학교, 한국연구재단

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