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Anti-obesity and Anti-diabetic Effects of the Fermented Ethanol Extracts from White Jelly Fungus (Tremella fuciformis Berk) with Lactobacillus rhamnosus BHN-LAB 76

Lactobacillus rhamnosus BHN-LAB 76로 발효한 흰목이버섯 (Tremella fuciformis Berk) 추출물의 항비만 및 항당뇨 효과

  • Yoon, Yeo-Cho (Institute for Development of Bioindustrial Materials, BHNBIO Co., Ltd.) ;
  • Kim, Byung-Hyuk (Institute for Development of Bioindustrial Materials, BHNBIO Co., Ltd.) ;
  • Kim, Jung-Gyu (Institute for Development of Bioindustrial Materials, BHNBIO Co., Ltd.) ;
  • Lee, Jun-Hyeong (Institute for Development of Bioindustrial Materials, BHNBIO Co., Ltd.) ;
  • Park, YeEun (Institute for Development of Bioindustrial Materials, BHNBIO Co., Ltd.) ;
  • Park, Hye-Suk (Institute for Development of Bioindustrial Materials, BHNBIO Co., Ltd.) ;
  • Hwang, Hak-Soo (Kyochon F&B Co., Ltd.) ;
  • Kwon, Gi-Seok (Division of Horticulture & Medicinal Plant, Andong National University) ;
  • Lee, Jung-Bok (Institute for Development of Bioindustrial Materials, BHNBIO Co., Ltd.)
  • 윤여초 ((주)비에이치앤바이오 생물산업소개발연구소) ;
  • 김병혁 ((주)비에이치앤바이오 생물산업소개발연구소) ;
  • 김중규 ((주)비에이치앤바이오 생물산업소개발연구소) ;
  • 이준형 ((주)비에이치앤바이오 생물산업소개발연구소) ;
  • 박예은 ((주)비에이치앤바이오 생물산업소개발연구소) ;
  • 박혜숙 ((주)비에이치앤바이오 생물산업소개발연구소) ;
  • 황학수 (교촌 F&B(주)) ;
  • 권기석 (안동대학교 원예.생약융합학부) ;
  • 이중복 ((주)비에이치앤바이오 생물산업소개발연구소)
  • Received : 2018.11.27
  • Accepted : 2019.01.17
  • Published : 2019.09.28

Abstract

White jelly fungus (Tremella fuciformis Berk; TF) has been used as a traditional medicine in Asia; it is known to prevent hypertension, aging, cancer, and arteriosclerosis. This study aimed to investigate the anti-diabetic effects of fermented Tremella fuciformis Berk (FTF) ethanol extracts fermented with L. rhamnosus BHN-LAB 76. We show that FTF increases the ${\alpha}$-glucosidase inhibitory activity and suppress the adipogenesis of 3T3-L1 adipocytes. These inhibitory effects of FTF are accompanied by the regulation of the phosphorylation of AMPK, JNK, and Akt. These data demonstrate that FTF not only inhibits adipogenesis by affecting the adipogenic signaling, but also increases the anti-diabetic effects by regulating the insulin signaling pathway. Therefore, we suggest that the FTF can be used for developing functional food and cosmetics materials.

Keywords

Anti-obesity activity;anti-diabetic activity;biological activity;lactic acid bacteria;Tremella fuciformis Berk

Acknowledgement

Supported by : Ministry of SMEs and Startups (MSS)

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