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Oral Manifestation of Paraneoplastic Pemphigus

Kim, Seurin;Park, In Hee;Park, YounJung;Kwon, Jeong-Seung;Choi, Jong-hoon;Ahn, Hyung-Joon

  • Received : 2019.06.14
  • Accepted : 2019.07.09
  • Published : 2019.09.30

Abstract

Paraneoplastic pemphigus (PNP) is a rare and often fatal autoimmune blistering disease accompanied by both benign and malignant neoplasms. Usually, oral, skin, and mucosal lesions are the earliest manifestations shown by PNP patients. Oral ulcers are initial lesions in various autoimmune diseases like pemphigus, bullous pemphigoid, erythema multiforme, graft-versus-host, lichen planus, it does not improved despite of high-dose steroid therapy. We report a-35-year-old female who presented oral ulceration, lip crust and skin lesions. By doing several examinations, such as enzyme-linked immunosorbent assay, incisional biopsy with indirect immunofluorescence, she was diagnosed PNP with non-Hodgkin's lymphoma on pancreas.

Keywords

Enzyme-linked immunosorbent assay;Fluorescent antibody technique, indirect;Oral ulcer;Pemphigus

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)