Antimalarial Activity and Phytochemical Profile of Ethanolic and Aqueous Extracts of Bidara Laut (Strychnos ligustrina Blum) Wood

  • MANURUNG, Harisyah (Department of Forest Products, Faculty of Forestry, IPB University (Bogor Agricultural University)) ;
  • SARI, Rita Kartika (Department of Forest Products, Faculty of Forestry, IPB University (Bogor Agricultural University)) ;
  • SYAFII, Wasrin (Department of Forest Products, Faculty of Forestry, IPB University (Bogor Agricultural University)) ;
  • CAHYANINGSIH, Umi (Department of Animal Health and Veterinary Medicine, Faculty of Veterinary, IPB University (Bogor Agricultural University)) ;
  • EKASARI, Wiwied (Department of Pharmacognosy and Phytochemical, Faculty of Pharmacy, Airlangga University)
  • Received : 2019.01.21
  • Accepted : 2019.08.10
  • Published : 2019.09.25


This study aimed to determine the antimalarial effect of the Strychnos ligustrina (SLW) wood extracts and to analyze its phytochemicals. The SLW powder samples were macerated with 100% ethanol (E100), 75% ethanol (E75), 50% ethanol (E50), 25% ethanol (E25), and aqueous (A100). The extracts were analyzed by LCMS/MS, and its in-vitro antimalarial activity was tested with Plasmodium falciparum. The results showed that the extract yields of E100, E75, E50, E25, and A100 were 4.3, 5.2, 5.3, 4.7, and 3.6%, respectively. The antimalarial activities of the A100, E25, E50, and E75 extracts were classified as active with $IC_{50}$ values of 38.6, 42.6, 42.9, and $43.7{\mu}g/mL$, respectively. But, the antimalarial activity of the E100 extract was classified as slightly active with $IC_{50}$ values of $87.4{\mu}g/mL$. The dominant compounds contained in the extracts of A100, E25, E50, E75, and E100 was the alkaloid compound, namely brucine with relative concentrations of 24.96, 24.55, 21.33, 11.79, and 11.62%, respectively.


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