A Study on the Function and Role of Morinda citrifolia L. (Noni)

노니의 기능 및 역할에 관한 연구

Hwang, Hyo-Jeong;Shin, Kyung-Ok;Han, Kyoung-Sik

  • Received : 2019.06.11
  • Accepted : 2019.08.06
  • Published : 2019.08.31


This study was carried out to investigate the various roles and effects of Morinda citrifolia L.(noni) on the human body and to utilize the findings obtained for future disease related research on food and nutrition. Morinda citrifolia L. has been used in folk medicine by Polynesians for over 2,000 years and is reported to have a broad range of therapeutic effects. Noni is an alkaloid system such as proxeronine, scopoletin, octanoic acid, terpenoids, alkaloids, anthraquinones, nordamnacanthal, morindone, rubiadin, b-sitosterol, flavone glycosides, linoleic acid, acubin, L-asperuloside, caproic acid, caprylic acid, ursolic acid, rutin. Noni's side effects have been reported to affect anti-inflammatory, analgesics, LDL antioxidant, anti-tumor, antifungal, antibiotic, antiviral, antiparasitic and immunosuppressive effects. In particular, noni's efficacy is considered to be important for the prevention of diseases by inhibiting active oxygen, which is a direct cause of oxidative stress, through various metabolites through 'xeronine system'. Noni's functions and effects that have been examined in this study include anti-inflammation, pain relief, antioxidant, anticancer, hepatocyte protection among others. Therefore, noni's extracts are considered highly useful for diverse scientific and nutritional health functional foods.


Morinda citrifolia L.;xeronine;chronic pain;antiinflammation;antioxidant


  1. Xue W, Warshawsky D. 2005. Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: A review. Toxicol Appl Pharmacol 206:73-93
  2. Yang J, Gadi R, Thomson T. 2011. Antioxidant capacity, total phenols, and ascorbic acid content of noni (Morinda citrifolia) fruits and leaves at various stages of maturity. Micronesica 41:167-176
  3. Yoo JS, Hwang JT, Yoo ES, Cheun BS. 2004. Study on herbal extract on the noni (Morinda citriforia). Korean J Biotechnol Bioeng 19:110-112
  4. Yoon JA, Shin KO. 2018. Studies on the biological activity of synbiotics: A review. Korean J Food Nutr 31:319-327
  5. Younos C, Rolland A, Fleurentin J, Lanhers MC, Misslin R, Mortier F. 1990. Analgesic and behavioural effects of Morinda citrifolia. Planta Med 56:430-443
  6. Zin ZM, Abdul-Hamid A, Osman A. 2002. Antioxidative activity of extracts from Mengkudu (Morinda citrifolia L.) root, fruit and leaf. Food Chem 78:227-231
  7. Ahmad MS, Sheeba AA, Rai KB. 2012. Cancer preventive effect of Morinda citrifolia (noni) fruit juice against the aflatoxin-B1-induced genotoxicity in human peripheral lymphocytes in vitro. IOSR J Pharm 2:228-234
  8. Allemann IB, Baumann L. 2008. Antioxidants used in skin care formulations. Skin Ther Lett 13:5-9
  9. Aniya Y, Koyama T, Miyagi C, Miyahira M, Inomata C, Kinoshita S, Ichiba T. 2005. Free radical scavenging and hepatoprotective actions of the medicinal herb, Crassocephalum crepidioides from the Okinawa Islands. Biol Pharm Bull 28:19-23
  10. Baker CL Jr, Ferguson CM. 2005. Future treatment of osteoarthritis. Orthopedics 28:227-234
  11. Basar S, Uhlenhut K, Hogger P, Schone F, Westendorf J. 2010. Analgesic and antiinflammatory activity of Morinda citrifolia L. (noni) fruit. Phytother Res 24:38-42
  12. Bostrom CE, Gerde P, Hanberg A, Jernstrom B, Johansson C, Kyrklund T, Rannug A, Tornqvist M, Victorin K, Westerholm R. 2002. Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air. Environ Health Perspect 110:451-488
  13. Brown AC. 2012. Anticancer activity of Morinda citrifolia (noni) fruit: A review. Phytother Res 26:1427-1440
  14. Chan-Blanco Y, Vaillant F, Perez AM, Reynes M, Brillouet JM, Brat P. 2006. The noni fruit (Morinda citrifolia L.): A review of agricultural research, nutritional and therapeutic properties. J Food Compos Anal 19:645-654
  15. Davis L, Kuttan G. 2000. Immunomodulatory activity of Withania somnifera. J Ethnopharmacol 71:193-200
  16. Dittmar A. 1993. Morinda citrifolia L.-Use in indigenous Samoan medicine. J Herbs Spices Med Plants 1:77-92
  17. Dixon AR, McMillen H. Etkin NL. 1999. Ferment this: The transformation of noni, a traditional Polynesian medicine (Morinda citrifolia, Rubiaceae). Econ Bot 53:51-68
  18. Duncan SH, Flint HJ, Stewart CS. 1998. Inhibitory activity of gut bacteria against Escherichia coli O157 mediated by dietary plant metabolites. FEMS Microbiol Lett 164:283-288
  19. Ettarch RR, Emeka P. 2004. Morinda lucida extract induces endothelium- dependent and -independent relaxation of rat aorta. Fitoterpia 75:332-336
  20. Farber E. 1984. The multistep nature of cancer development. Cancer Res 44:4217-4223
  21. Farine JP, Legal L, Moreteau B, Le Quere JL. 1996. Volatile components of ripe fruits of Morinda citrifolia and their effects on Drosophila. Phytochemistry 41:433-438
  22. Furusawa E, Hirazumi A, Story S, Jensen J. 2003. Antitumour potential of a polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) on sarcoma 180 ascites tumour in mice. Phytother Res 17:1158-1164
  23. Gokce N, Keaney JF Jr, Frei B, Holbrook M, Olesiak M, Zachariah BJ, Leeuwenburgh C, Heinecke JW, Vita JA. 1999. Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 99:3234-3240
  24. Heinicke RM. 1983. Xeronine, a new alkaloid, useful in medical, food and industrial fields. US Patent 4,409,144
  25. Heinicke RM. 1985. The pharmacologically active ingredient of noni. Pac Trop Bot Gard Bull 15:10-14
  26. Higa I, Fuyama Y. 1993. Genetics of food preference in Drosophila sechellia. I. Responses to food attractants. Genetica 88:129-136
  27. Hirazumi A, Furusawa E. 1999. An immunomodulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) with antitumour activity. Phytother Res 13:380-387<380::AID-PTR463>3.0.CO;2-M
  28. Hornick CA, Myers A, Sadowska-Krowicka H, Anthony CT, Woltering EA. 2003. Inhibition of angiogenic initiation and disruption of newly established human vascular networks by juice from Morinda citrifolia (noni). Angiogenesis 6:143-149
  29. Hulejova H, Baresova V, Klezl Z, Polanska M, Adam M, Senolt L. 2007. Increased level of cytokines and matrix metalloproteinases in osteoarthritic subchondral bone. Cytokine 38:151-156
  30. Jainkittivong A, Butsarakamruha T, Langlais RP. 2009. Antifungal activity of Morinda citrifolia fruit extract against Candida albicans. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:394-398
  31. Joharapurkar AA, Zambad SP, Wanjari MM, Umathe SN. 2003. In vivo evaluation of antioxidant activity of alcoholic extract of Rubia cordifolia Linn. and its influence on ethanol-induced immunosuppression. Indian J Pharmacol 35:232-236
  32. Kamiya K, Tanaka Y, Endang H, Umar M, Satake T. 2004. Chemical constituents of Morinda citrifolia fruits inhibit copper-induced low-density lipoprotein oxidation. J Agric Food Chem 52:5843-5848
  33. Kim SH, Jun CD, Suk K, Choi BJ, Lim H, Park S, Lee SH, Shin HY, Kim DK, Shin TY. 2006. Gallic acid inhibits histamine release and pro-inflammatory cytokine production in mast cells. Toxicol Sci 91:123-131
  34. Legal L, Chappe B, Jallon JM. 1994. Molecular basis of Morinda citrifolia (L.): Toxicity on drosophila. J Chem Ecol 20:1931-1943
  35. Levand O, Larson HO. 1979. Some chemical constituents of Morinda citrifolia. Planta Med 36:186-187
  36. Li RW, Myers SP, Leach DN, Lin GD, Leach G. 2003. A cross-cultural study: Anti-inflammatory activity of Australian and Chinese plants. J Ethnopharmacol 85:25-32
  37. Liu SL, Degli Esposti S, Yao T, Diehl AM, Zern MA. 1995. Vitamin E therapy of acute $CCl_{4}$-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding. Hepatology 22:1474-1481
  38. Locher CP, Burch MT, Mower HF, Berestecky J, Davis H, Van Poel B, Lasure A, Vanden Berghe DA, Vlietinck AJ. 1995. Anti-microbial activity and anti-complement activity of extracts obtained from selected Hawaiian medicinal plants. J Ethnopharmacol 49:23-32
  39. Mathivanan N, Surendiran G, Srinivasan K, Sagadevan E, Malarvizhi K. 2005. Review on the current scenario of noni research: Taxonomy, distribution, chemistry, medicinal and therapeutic values of Morinda citrifolia. Int J Noni Res 1:1-16
  40. McClatchey W. 2002. From Polynesian healers to health food stores: Changing perspectives of Morinda citrifolia (Rubiaceae). Integr Cancer Ther 1:110-120
  41. Mckoy MG, Thomas EA, Simon OR. 2002. Preliminary investigation of the anti-inflammatory properties of an aqueous extract from Morinda citrifolia (noni). Proc West Pharmacol Soc 45:76-78
  42. Mohd Zin Z, Abdul Hamid A, Osman A, Saari N, Misran A. 2007. Isolation and identification of antioxidative compound from fruit of mengkudu (Morinda citrifolia L.). Int J Food Prop 10:363-373
  43. Morton JF. 1992. The ocean-going noni, or Indian mulberry (Morinda citrifolia, Rubiaceae) and some of its "colorful" relatives. Econ Bot 46:241-256
  44. Motshakeri M, Ghazali HM. 2015. Nutritional, phytochemical and commercial quality of noni fruit: A multi-beneficial gift from nature. Trends Food Sci Technol 45:118-129
  45. Nayak BS, Marshall JR, Isitor G, Adogwa A. 2011. Hypoglycemic and hepatoprotective activity of fermented fruit juice of Morinda citrifolia (noni) in diabetic rats. J Evidence-Based Complementary Altern Med p.875293
  46. Nayak S, Mengi S. 2010. Immunostimulant activity of noni (Morinda citrifolia) on T and B lymphocytes. Pharm Biol 48:724-731
  47. Oh HI, Park HB, Ju MS, Jung SY, Oh MS. 2010. Comparative study of anti-oxidant and anti-inflammatory activities between Curcumae longae radix and Curcumae longae rhizoma. Korea J Herbol 25:83-91
  48. Ohara Y, Peterson TE, Harrison DG. 1993. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 91:2546-2551
  49. Palu AK, Kim AH, West BJ, Deng S, Jensen J, White L. 2008. The effects of Morinda citrifolia L. (noni) on the immune system: Its molecular mechanisms of action. J Ethnopharmacol 115:502-506
  50. Pande M, Naiker M, Mills G, Singh N, Voro T. 2005. The Kura files: Qualitative social survey. Pac Health Dialog 12:85-93
  51. Pawlus AD, Kinghorn AD. 2007. Review of the ethnobotany, chemistry, biological activity and safety of the botanical dietary supplement Morinda citrifolia (noni). J Pharm Pharmacol 59:1587-1609
  52. Peter PI. 2007. Clinical research on Morinda citrifolia L.- noni. Noni Cli Res J 1:4-19
  53. Pirmohamed M, James S, Meakin S, Green C, Scott AK, Walley TJ, Farrar K, Park BK, Breckenridge AM. 2004. Adverse drug reactions as cause of admission to hospital: Prospective analysis of 18 820 patients. BMJ 3:15-19
  54. Pitot HC, Sirica AE. 1980. The stages of initiation and promotion in hepatocarcinogenesis. Biochim Biophys Acta (BBA) Rev Cancer 605:191-215
  55. Prasad V, Jain V, Dorle AK. 2006. Evaluation of Momordica charantia ghrita for immunomodulatory activity. J Plant Sci 1:80-85
  56. Punjanon T, Nandhasri P. 2005. Analgesic effect of the alcoholic extract from the fruits of Morinda citrifolia. pp.103-106, ISHS Acta Horticulturae 678: III WOCMAP Congress on Medicinal and Aromatic Plants
  57. Ramesh S, Radhakrishnan M, Anburaj R, Elangomathavan R, Patharajan S. 2012. Physicochemical, phytochemical and antimicrobial studies on Morinda citrifolia L. fruits at different maturity stages. Int J Pharm Pharm Sci 4:473-476
  58. Rethinam P, Sivaraman K. 2007. Noni (Morinda citrifolia L.) - the miracle fruit: A holistic review. Int J Noni Res 2:4-37
  59. Saludes JP, Garson MJ, Franzblau SG, Aguinaldo AM. 2002. Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae). Phytother Res 16:683-685
  60. Seifert WF, Bosma A, Hendriks HF, van Leeuwen RE, van Thiel-de Ruiter GC, Seifert-Bock I, Knook DL, Brouwer A. 1995. Beta-carotene (provitamin A) decreases the severity of $CCl_4$-induced hepatic inflammation and fibrosis in rats. Liver 15:1-8
  61. Singh DR. 2012. Morinda citrifolia L. (noni): A review of the scientific validation for its nutritional and therapeutic properties. J Diabetes Endocrinol 3:77-91
  62. Stocker R, Keaney JF Jr, 2004. Role of oxidative modifications in atherosclerosis. Physiol Rev 84:1381-1478
  63. Sunder J, Jeyakumar S, Sujatha T, Kundu A. 2013. Effect of feeding of Morical: A herbal based supplement on production and egg quality in Japanese quails. Adv Anim Vet Sci 1:157-160
  64. Swanholm CE, St John H, Scheuer PJ. 1959. A survey for alkaloids in Hawaiian plants. I. Pac Sci 13:295-305
  65. Tabrah FL, Eveleth BM. 1966. Evaluation of the effectiveness of ancient Hawaiian medicine. Hawaii Med J 25:223-230
  66. Vane JR, Botting RM. 1998. Mechanism of action of nonsteroidal anti-inflammatory drugs. Am J Med 104:2S-8S
  67. Wang M, Kikuzaki H, Csiszar K, Boyd CD, Maunakea A, Fong SF, Ghai G, Rosen RT, Nakatani N, Ho CT. 1999. Novel trisaccharide fatty acid ester identified from the fruits of Morinda citrifolia (noni). J Agric Food Chem 47:4880-4882
  68. Wang MY, Lutfiyya MN, Weidenbacher-Hoper V, Anderson G, Su CX, West BJ. 2009. Antioxidant activity of noni juice in heavy smokers. Chem Cent J 3:13
  69. Wang MY, Nowicki D, Anderson G, Jensen J, West B. 2008. Liver protective effects of Morinda citrifolia (noni). Plant Food Hum Nutr 63:59-63
  70. Wang MY, Su C. 2001. Cancer preventive effect of Morinda citrifolia (noni). Ann N Y Acad Sci 952:161-168
  71. Wang MY, West BJ, Jensen CJ, Nowicki D, Su C, Palu A K, Anderson G. 2002. Morinda citrifolia (noni): A literature review and recent advances in noni research. Acta Pharmacol Sin 23:1127-1141
  72. West BJ, Deng S, Palu AK, Jensen CJ. 2009. Morinda citrifolia Linn. (Rubiaceae) leaf extracts mitigate UVB-induced erythema. J Nat Med 63:351-354
  73. Whistler WA. 1992. Tongan Herbal Medicine. pp.89-90. University of Hawaii Press
  74. Willcox JK, Ash SL, Catignani GL. 2004. Antioxidants and prevention of chronic disease. Crit Rev Food Sci Nutr 44:275-295


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