Suppressing Effects of Ethanol Extract from Dioscoreae Rhizoma on atope Dermatitis

부채마 에탄올 추출물의 아토피 피부염 억제 효과

  • Do, Young-Bog (Graduate School of Public Health, Daejeon University) ;
  • Song, Young-Soon (Graduate School of Oriental Culture Graduate School of Medicinai Crop Science)
  • 도영복 (대전대학교 보건의료대학원) ;
  • 송영순 (동방문화대학원대학교 약용작물학)
  • Received : 2019.05.26
  • Accepted : 2019.08.20
  • Published : 2019.08.28


This study was conducted to investigate the effect of 70% ethanol extract (DR) on the mast cell-mediated allergic contact dermatitis induced by dinitrofluorobenzene in BALB / c mice, which affects the cell activity by antigen in RBL-2H3 mast cells Respectively. The ethanol extracts of RBL-2H3 cells activated by DNP-HSA and anti-DNP IgE antibodies inhibited the secretion of ${\beta}$-hexosaminidase, histamine, and IL-4 and $TNF-{\alpha}$ Production was suppressed. In the DNFB-induced contact allergic dermatitis animal model, treatment with ethanol extract reduced ear swelling and inhibited serum histamine and IL-4 secretion, and DR treatment effectively prevented mast cell infiltration in dermatitis-induced areas. As a result, the ethanol extract may be used as a therapeutic agent for mast cell-mediated allergic diseases such as atopic dermatitis.


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