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Therapeutic strategies to manage chronic wounds by using biofilm dispersal mechanisms

생물막 분산기작을 이용한 만성창상의 치료전략

Kim, Jaisoo;Kim, Min-Ho
김재수;김민호

  • Received : 2019.04.04
  • Accepted : 2019.05.09
  • Published : 2019.06.30

Abstract

Most chronic wounds persist in the inflammatory phase during wound healing due to the biofilm. Biofilms are resistant to antibiotics, weakening penetration, resistance to biocides and weakening local immune responses. The biofilm is firmly attached to the surrounding tissues and is very difficult to remove. Therefore, strategies to remove hard biofilms without damaging surrounding tissue are very important. One of possible strategies is dispersal. So many studies have been done to develop new strategies using dispersal mechanisms. In this review paper, especially chemotaxis, phage therapy, polysaccharides, various enzymes (glycosidases, proteases, and deoxyribonucleases), surfactants, dispersion signals, autoinducers, inhibitors were introduced. Combination therapies with other therapies such as antibiotic therapy were also introduced. It is expected that the possibility of treatment of chronic wound infection using the knowledge of the biofilm dispersal mechanisms presented in this paper will be higher.

Keywords

antibiotics;biofilm;chronic wound;dispersal;therapeutic strategy

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