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MicroRNA-374a Expression as a Prognostic Biomarker in Lung Adenocarcinoma

  • Kim, Yeseul (Department of Pathology, Hanyang University College of Medicine) ;
  • Sim, Jongmin (Department of Pathology, Samsung Medical Center) ;
  • Kim, Hyunsung (Department of Pathology, Hanyang University College of Medicine) ;
  • Bang, Seong Sik (Department of Pathology, Hanyang University College of Medicine) ;
  • Jee, Seungyun (Department of Pathology, Hanyang University College of Medicine) ;
  • Park, Sungeon (Department of Pathology, Hanyang University College of Medicine) ;
  • Jang, Kiseok (Department of Pathology, Hanyang University College of Medicine)
  • Received : 2019.07.17
  • Accepted : 2019.10.01
  • Published : 2019.11.15

Abstract

Background: Lung cancer is the most common cause of cancer-related death, and adenocarcinoma is the most common histologic subtype. MicroRNA is a small non-coding RNA that inhibits multiple target gene expression at the post-transcriptional level and is commonly dysregulated in malignant tumors. The purpose of this study was to analyze the expression of microRNA-374a (miR-374a) in lung adenocarcinoma and correlate its expression with various clinicopathological characteristics. Methods: The expression level of miR-374a was measured in 111 formalin-fixed paraffin-embedded lung adenocarcinoma tissues using reverse transcription-quantitative polymerase chain reaction assays. The correlation between miR-374a expression and clinicopathological parameters, including clinical outcome, was further analyzed. Results: High miR-374 expression was correlated with advanced pT category (chi-square test, p=.004) and pleural invasion (chi-square test, p=.034). Survival analysis revealed that patients with high miR-374a expression had significantly shorter disease-free survival relative to those with low miR-374a expression (log-rank test, p=.032). Conclusions: miR-374a expression may serve as a potential prognostic biomarker for predicting recurrence in early stage lung adenocarcinoma after curative surgery.

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