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Genome sequence of Veillonella atypica KHUD-V1 isolated from a human subgingival dental plaque of periodontitis lesion

사람 치주염 병소의 치은 연하 치태에서 분리된 Veillonella atypica KHUD-V1의 유전체 염기서열 해독

  • Lee, Jae-Hyung (Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University) ;
  • Shin, Seung-Yun (Department of Periodontology, School of Dentistry, Kyung Hee University) ;
  • Lee, Han (Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University) ;
  • Yang, Seok Bin (Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University) ;
  • Jang, Eun-Young (Department of Dentistry, Graduate School, Kyung Hee University) ;
  • Ryu, Jae-In (Department of Preventive Dentistry, School of Dentistry, Kyung Hee University) ;
  • Lee, Jin-Yong (Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University) ;
  • Moon, Ji-Hoi (Department of Maxillofacial Biomedical Engineering, School of Dentistry, Kyung Hee University)
  • 이재형 (경희대학교 치과대학 악안면생체공학교실) ;
  • 신승윤 (경희대학교 치과대학 치주과학교실) ;
  • 이한 (경희대학교 치과대학 악안면생체공학교실) ;
  • 양석빈 (경희대학교 치과대학 악안면생체공학교실) ;
  • 장은영 (경희대학교 대학원 치의학과) ;
  • 류재인 (경희대학교 치과대학 예방치과학교실) ;
  • 이진용 (경희대학교 치과대학 악안면생체공학교실) ;
  • 문지회 (경희대학교 치과대학 악안면생체공학교실)
  • Received : 2018.11.26
  • Accepted : 2019.01.22
  • Published : 2019.03.31

Abstract

Here we report the genome sequence of Veillonella atypica strain KHUD-V1 isolated from subgingival dental plaque of Korean chronic periodontitis patients. Unlike other V. atypica strains, KHUD-V1 carries two prophage regions and prophage remnants, as well as several genes homologous to prophage-associated virulence factors, such as virulence-associated protein E, a Clp protease, and a toxin-antitoxin system. The isolate and its genome sequence obtained here will aid to understand the diversity of the genome architecture of Veillonella within an evolutionary framework and the role of prophages that contribute to the genetic diversity as well as the virulence of V. atypica.

Keywords

Veillonella atypicau;genome;periodontitis;prophage

MSMHBQ_2019_v55n1_77_f0001.png 이미지

Fig. 1. Prophages present in Veillonella atypica KHUD-V1.

Table 1. Genome features of Veillonella atypica KHUD-V1

MSMHBQ_2019_v55n1_77_t0001.png 이미지

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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