The Effect of Selaginella tamariscina on Inhibition of Pancreatic Lipase and Lipid Accumulation

부처손(Selaginella tamariscina) 추출물의 리파아제 저해 활성 및 지질 축적 억제 효과

  • Kim, Gun-Hee (Plant Resources Research Institute, Duksung Women's University) ;
  • Lee, Shin-Young (Plant Resources Research Institute, Duksung Women's University) ;
  • Lee, Ae-Rang (Dept. of Food and Nutrition, SoongEui Women's College)
  • 김건희 (덕성여자대학교 식물자원연구소) ;
  • 이신영 (덕성여자대학교 식물자원연구소) ;
  • 이애랑 (숭의여자대학교 식품영양과)
  • Received : 2018.12.01
  • Accepted : 2019.01.23
  • Published : 2019.02.28


The objective of this study was to evaluate novel usability as natural anti-obesity supplement of Selaginella tamariscina extract. The total phenol contents and total flavonoid contents were $60.29{\pm}3.11GAE\;mg/g$ and $14.90{\pm}0.34QE\;mg/g$, respectively. To evaluate anti-obesity activity of Selaginella tamariscina extract, pancreatic lipase inhibition activity as well as its inhibition effect of lipid accumulation in adipocytes were conducted by Oil Red O staining and lipolysis assay. The result of pancreatic lipase inhibition activity of S. tamariscina extract showed a wide range between 40 and 73% dose dependently. While the incubation of 3T3-L1 cells with S. tamariscina extract inhibited differentiation of preadipocytes and reduced lipid accumulation, the level of released free glycerol into culturing medium was increased in multiple concentrations. These results showed that S. tamariscina extract inhibit adipogenesis and pancreatic lipase activity. Thus, S. tamariscina extract can be a candidate for regulating lipid accumulation in obesity.

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Fig. 1. Inhibitory effect on pancreatic lipase of Selaginella tamariscina.

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Fig. 2. Cell viability of Selaginella tamariscina.

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Fig. 3. Inhibitory effect on fat accumulation of Selaginella tamariscina.

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Fig. 4. Effect of Selaginella tamariscina on glycerol release in 3T3-L1 cell.

Table 1. The yield, total phenol contents and total flavonoid contents of Selaginella tamariscina extract

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Supported by : 율촌재단


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