Effects of Anti-ecotoxicological Curcumin Nanospheres on Feed Efficiency and Fecal Odor in Mice

환경 독성 억제효과를 가진 커큐민 나노스피어가 마우스의 사료 효율 및 악취저감에 미치는 영향

  • Park, Jeong-Bae (Department of Pharmaceutical Engineering, Daegu Haany University) ;
  • Lee, Young-Min (Department of Pharmaceutical Engineering, Daegu Haany University) ;
  • Park, Moon-Ki (Department of Pharmaceutical Engineering, Daegu Haany University) ;
  • Min, Taesun (Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University) ;
  • Lee, Sei-Jung (Department of Pharmaceutical Engineering, Daegu Haany University)
  • 박정배 (대구한의대학교 제약공학과) ;
  • 이영민 (대구한의대학교 제약공학과) ;
  • 박문기 (대구한의대학교 제약공학과) ;
  • 민태선 (제주대학교 생명공학과) ;
  • 이세중 (대구한의대학교 제약공학과)
  • Received : 2019.01.18
  • Accepted : 2019.02.12
  • Published : 2019.02.28


Curcumin ($C_{21}H_{20}O_6$) is a hydrophobic polyphenol found in turmeric. Although curcumin has been used as a natural medicine, its major limitation is related to poor absorption from the gut. Therefore, we developed a method for preparation of Curcumin Nanospheres (CN) to improve the aqueous-phase solubility of curcumin and investigate the functional role of CN in promoting feed efficiency and odor reduction in mice. CN showed inhibitory effects on actate dehydrogenase (LDH) cytotoxicity induced by ecotoxic substance toluene in gut epithelial HCT116 cells. In addition, the weights of internal organs (liver, heart, kidneys, and spleen) and the levels of serum Glutamate Oxaloacetate Transaminase (GOT), Glutamate Pyruvate Transaminase (GPT), and LDH did not show significant differences between mice administered oral CN for two weeks and compared to the control group. Interestingly, CN not only reduced hydrogen sulfide ($H_2S$) and ammonia ($NH_3$) levels and fecal odor, but also improved feed efficiency in mice. These results demonstrate that oral nano-delivery of anti-ecotoxicological CN is a functional system to deliver curcumin to the gut to improve feed efficiency and reduce fecal odor in mice.


Curcumin nanospheres;Ecotoxic substance;Feed efficiency;Odor reduction;Toluene


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