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Evaluation of Clinically Effective Doses of Triamcinolone Acetonide for Intralesional Injection in Oral Lichen Planus

Park, Su-Hyeon;Lee, Hae-Ohk;Ju, Hye-Min;Lee, Ji-Yeon;Jeon, Hye-Mi;Ok, Soo-Min;Ahn, Yong-Woo;Jeong, Sung-Hee

  • Received : 2019.10.19
  • Accepted : 2019.03.07
  • Published : 2019.03.30

Abstract

Purpose: The aim of this study was to evaluate the optimal doses of intralesional triamcinolone acetonide (TA) in the treatment of oral lichen planus (OLP). Methods: A randomized clinical trial was performed. Sixty-two lesions of OLP were received 12 mg (group A) or 20 mg (group B) of TA intralesionally weekly for 2 weeks. Subjective symptoms, lesion size, favorable conversion of clinical subtypes, and clinical response were evaluated at weeks 0, 1, 2, and 4. Results: After two consecutive injections of TA, group B showed significant reduction in burning sensation and reticular area (p<0.01). Favorable conversion and complete response were greater in group B. Mild oral candidiasis was developed in group B (10.7%). Conclusions: A 20-mg injection of TA was much more effective compared with 12-mg injection of TA in the treatment of OLP.

Keywords

Intralesional injections;Oral lichen planus;Triamcinolone acetonide