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Establishment of the Male Menopause Animal Model Using Rats

랫드를 활용한 남성갱년기 동물모델의 확립

  • 이수정 ((재)베리&바이오식품연구소) ;
  • 권규택 ((재)베리&바이오식품연구소) ;
  • 최혜란 ((재)베리&바이오식품연구소) ;
  • 김성웅 ((재)베리&바이오식품연구소) ;
  • 최도현 (삼육대학교 동물생명자원학과) ;
  • 공현석 (삼육대학교 동물생명자원학과) ;
  • 권지웅 ((재)베리&바이오식품연구소) ;
  • 신대근 ((재)베리&바이오식품연구소) ;
  • 이상진 (삼육대학교 동물생명자원학과)
  • Received : 2018.03.02
  • Accepted : 2018.09.05
  • Published : 2018.10.31

Abstract

The level of testosterone in the blood decreases in males with age, resulting in menopausal symptoms. As the rat reproductive system is very similar to humans, the rats(Ratus norvegicus) commonly used in scientific studies, have been domesticated for more than one hundred years. Therefore, in order to establish an animal model of male menopause, this study was conducted to obtain data on the changes in major hormones and biochemical changes, including testosterone and weight changes in reproductive organs in the two groups of 22 and 50 weeks old rats. The weights of body and reproductive organs were greater at 50 weeks of age than at 22 weeks of age. However, DHT level in serum was higher at 22 weeks than at 50 weeks. In addition, significant increase in AST, ALP, total protein, triglyceride and total cholesterol levels was detected at 50 weeks. The levels of testosterone, LH and sperm concentration and motilitywereremarkably decreased in 50 weeks old rats. The serum FSH level did not change between the two groups. Therefore, it appears that 50 weeks old rats are appropriate and eligible as an animal model of male menopause. Further studies are needed to confirm the changes in various factors according to periods of growth through continuous experiments.

Acknowledgement

Supported by : 농림축산식품부, 한국연구재단, 삼육대학교

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