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Precision Medicine in Castration-Resistant Prostate Cancer

거세저항성전립선암에서 정밀의학에 대한 고찰

  • Kim, Won Tae (Department of Urology, College of Medicine, Chungbuk National University) ;
  • Yun, Seok Joong (Department of Urology, College of Medicine, Chungbuk National University) ;
  • Kim, Wun-Jae (Department of Urology, College of Medicine, Chungbuk National University)
  • 김원태 (충북대학교 의과대학 비뇨의학과교실) ;
  • 윤석중 (충북대학교 의과대학 비뇨의학과교실) ;
  • 김원재 (충북대학교 의과대학 비뇨의학과교실)
  • Received : 2018.11.21
  • Accepted : 2018.12.05
  • Published : 2018.12.30

Abstract

Prostate cancer is usually managed by androgen deprivation therapy after failure of primary treatment. However, such therapies are only temporarily effective in prostate cancer patients, and the most patients experience the progression to castration-resistant prostate cancer (CRPC). Docetaxel chemotherapy is conventional effective treatment for CRPC but has many adverse effects. In CRPC patients, treatment decisions were not typically base on the recognitions of inter-individual differences. Therefore, there are growing interests for precision medicine in CRPC. In this review, we summarized the precision medicine such as candidate target genes and potential therapies in CRPC.

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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