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Effects of KIOM-79 on streptozotocin-induced insulin-dependent diabetes in Sprague-Dawley rats

Streptozotocin을 이용한 제1형 당뇨 유발 흰쥐에서 KIOM-79의 효과

  • Lee, Jong Hyuk (Medical course, School of Medicine, Jeju National University) ;
  • Yoon, Sang-Pil (Department of Anatomy, School of Medicine, Jeju National University) ;
  • Kim, Jin-Sook (Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Chang, In-Youb (Department of Anatomy, School of Medicine, Chosun University)
  • 이종혁 (제주대학교 의학전문대학원 의학과) ;
  • 윤상필 (제주대학교 의학전문대학원 해부학교실) ;
  • 김진숙 (한국한의학연구원 한약연구부) ;
  • 장인엽 (조선대학교 의과대학 해부학교실)
  • Received : 2018.10.23
  • Accepted : 2018.11.07
  • Published : 2018.12.31

Abstract

We investigated the effect of KIOM-79, 80% ethanolic extract of herbal prescription isolated from Magnolia officinalis, Pueraria lobate, Glycyrrhiza uralensis, and Euphorbia pekinensis, on streptozotocin-induced diabetes in Sprague-Dawley rats. The rats were treated orally with KIOM-79 (500 mg/kg/day) 1) for 3 days prior to streptozotocin (60 mg/kg, intraperitoneal) injection or 2) for 9 weeks after establishing diabetes model to examine acute and chronic effects on hyperglycemia and biochemical variables, respectively. As a result, KIOM-79 had little effects on hyperglycemic changes in acute model. Sexual comparison, however, showed reduced hyperglycemia in female rats, especially 24 hours after streptozotocin injection with or without KIOM-79 pretreatment. In chronic model, streptozotocin-induced hyperglycemia was well established, but KIOM-79 treatment showed no statistically significant effects on all variables. Thus, based on our findings KIOM-79 might have little effects on streptozotocin-induced insulin-dependent diabetes although it has been known to have hypoglycemic and antidiabetic effects on non-insulin-dependent diabetes models.

Acknowledgement

Supported by : 과학기술부

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