Evaluation of Standardized Uptake Value applying EQ PET across different PET/CT scanners and reconstruction

PET/CT 장비와 영상 재구성 차이에 따른 EQ PET을 이용한 표준섭취계수의 평가

  • Yoon, Seok Hwan (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Kim, Byung Jin (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Moon, Il Sang (Department of Nuclear Medicine, Seoul National University Hospital) ;
  • Lee, Hong Jae (Department of Nuclear Medicine, Seoul National University Hospital)
  • 윤석환 (서울대학교병원 핵의학과) ;
  • 김병진 (서울대학교병원 핵의학과) ;
  • 문일상 (서울대학교병원 핵의학과) ;
  • 이홍재 (서울대학교병원 핵의학과)
  • Received : 2018.04.14
  • Accepted : 2018.04.30
  • Published : 2018.05.19

Abstract

Purpose Standardized uptake value(SUV) has been widely used as a quantitative metric of uptake in PET/CT for diagnosis of malignant tumors and evaluation of tumor therapy response. However, the SUV depends on various factor including PET/CT scanner specifications and reconstruction parameter. The purpose of this study is to validate a EQ PET to evaluate SUV across different PET/CT systems. Materials and Methods First, NEMA IEC body phantom data were used to calculate the EQ filter for OSEM3D with PSF and TOF reconstruction from three different PET/CT systems in order to obtain EARL compliant recovery coefficients of each spheres. The Biograph true point 40 PET/CT images were reconstructed with a OSEM3D+PSF reconstruction, images of the Biograph mCT 40 and Biograph mCT 64 PET/CT scanners were reconstructed with a OSEM3D+PSF, OSEM3D+TOF, OSEM3D+PSF+TOF. Post reconstructions, the proprietary EQ filter was applied to the reconstruction data. Recovery coefficient can be estimated by ratio of measured to true activity concentration for spheres of different volume and coefficient variability(CV) value of RC for each sphere was compared. For clinical study, we compared SUVmax applying different reconstruction algorithms in FDG PET images of 61 patients with lung cancer using Biograph mCT 40 PET/CT scanner. Results For the phantom studied, the mean values of CV for OSEM3D, OSEM3D+PSF, OSEM3D+TOF and OSEM3D+PSF+TOF reconstructions were 0.05, 0.04, 0.04 and 0.03 respectively for RC. Application of the proprietary EQ filter, the mean values of CV for OSEM3D, OSEM3D+PSF, OSEM3D+TOF and OSEM3D+PSF+TOF reconstructions were 0.04, 0.03, 0.03 and 0.02 respectively for RC. Clinical study, there were no statistical significance of the difference applying EQ PET on SUVmax of 61 patients FDG PET image. (p=1.000) Conclusion This study indicates that CV values of RC in phantom were decreased after applying EQ PET for different PET/CT system and The EQ PET reduced reconstruction dependent variation in SUVs for 61 lung cancer patients, Therefore, EQ PET will be expected to provide accurate quantification when the patient is scanned on different PET/CT system.

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