- Volume 41 Issue 2
DOI QR Code
Effects of CT Contrast Medium on the Relaxation Rate of MR Contrast Medium
CT 조영제가 MR 조영제의 이완율에 미치는 영향
- Kwon, Soon-Yong (Department of Radiology, Konkuk University Medical Center) ;
- Kang, Chung-Hwan (Department of Radiology, Konkuk University Medical Center) ;
- Jeong, Hyeon Keum (Department of Medical Imaging Engineering, Korea University) ;
- Park, Jin Seo (Department of Radiology, Konkuk University Medical Center) ;
- Kim, Seong-Ho (Department of Radiology, Konkuk University Medical Center)
- 권순용 (건국대학교병원 영상의학과) ;
- 강충환 (건국대학교병원 영상의학과) ;
- 정현근 (고려대학교대학원 의료영상공학과) ;
- 박진서 (건국대학교병원 영상의학과) ;
- 김성호 (건국대학교병원 영상의학과)
- Received : 2017.10.16
- Accepted : 2018.04.14
- Published : 2018.04.30
In MR, the iodine CT contrast medium reduces the T1 and T2 relaxation times of the substance, resulting in a change in signal intensity. This study aimed to measure the relaxation rate of MR contrast medium with or without diluting CT contrast medium and analyzed the effect of CT contrast medium. Undiluted Gadoteridol solution was diluted with saline to prepare MR contrast medium phantoms with various levels of Gadoteridol concentrations. Moreover, undiluted Iomeprol was mixed with the prepared MR contrast medium phantoms at 1:1 ratio to make MR contrast medium phantoms with containing CT contrast medium for the experiment. T1 and T2 mappings were conducted to quantitatively evaluate the relaxation time and relaxation rate of these phantoms. The results showed that the T1 and T2 relaxation time and relaxation rate of MR contrast medium diluted with CT contrast medium were significantly (p<0.05) shorter than those of MR contrast medium not diluted with CT contrast medium. The results of this study imply that, when MR contrast medium shall be used after injecting CT contrast medium, CT contrast medium should be discharged enough. Moreover, it would be desirable to conduct CT test after taking MRI test in order to reduce the effects of CT contrast medium on MR contrast medium.
- Gustav J. Strijkers, Willem J. Mulder. MRI Contrast Agents: Current Status and Future Perspectives. Anti-Cancer Agent in Medicinal Chemistry. 2007;7(3):291-305. https://doi.org/10.2174/187152007780618135
- Evan H. Dillon, Maarten S. van Leeuwen. Spiral CT Angiography. American Roentgen Ray Society. 1993;160(6):1273-1278. https://doi.org/10.2214/ajr.160.6.8498233
- Luis M. De Leon-Rodriguez, A. Dean Sherry. Basic MR Relaxation Mechanisms and Contrast Agent Design. Journal of Magnetic Resonance Imaging. 2015;42(3):545-565. https://doi.org/10.1002/jmri.24787
- Vincent H. Liu. Magnetic resonance imaging contrast agents for chemical sensing. MASSACHUSETTS INSTITUTE OF TECHNOLOGY; 2014.
- Arundhuti Ganguly, Garry E. Gold. Quantitative Evaluation of the Relaxivity Effects of Iodine on Gd-DTPA Enhanced MR Arthrography. Journal of Magnetic Resonance Imaging. 2007;25(6):1219-1225. https://doi.org/10.1002/jmri.20934
- Jinkins JR, Robinson JW, Sisk L, et al. Proton relaxation associated with iodinated contrast agents in MR imaging of the CNS. AJNR. 1992;13(1):19-27.
- Hergan K, Doringer W, Langle M, et al. Effect of iodinated contrast agents in MR imaging. Eur J Radiol. 1995;21(1):11-17. https://doi.org/10.1016/0720-048X(95)00677-I
- H Morales, L Lemen, R Samaratunga. Effects of iodinated contrast on various magnetic resonance imaging sequences and field strength: Implications for characterization of hemorrhagic transformation in acute stroke therapy. World J Radiol. 2016;8(6):588. https://doi.org/10.4329/wjr.v8.i6.588
- Dapeng Hao, Xuemei Hu. MRI Contrast Agent: Basic Chemistry and Safety. Journal of Magnetic Resonance Imaging. 2012;36(5):1060-1071. https://doi.org/10.1002/jmri.23725
- Peter Caravan, Jeffrey J. Ellison. Gadolinium (III) chelates as MRI contrast agents: structure, dynamics, and applications. American Chemical Society. 1999;99(9):2293-2352.
- Christoph de Haen. Conception of the First Magnetic Resonance Imaging Contrast Agent. Topic in Magnetic Resonance Imaging. 2001;12(4):221-230. https://doi.org/10.1097/00002142-200108000-00002
- Strijkers GJ, Mulder WJ. MRI contrast agents: current status and future perspectives. Anti-Cancer Agents in Medicinal Chemistry. 2007;7(3):291-305. https://doi.org/10.2174/187152007780618135
- Aime S1, Cabella C. Insights into the use of paramagnetic Gd (III) complexes in MR-molecular imaging investigations. Journal of magnetic resonance imaging. 2002;16(4):394-406. https://doi.org/10.1002/jmri.10180
- Hanns-Joachim Weinmann, Robert C. Brasch. Characteristics of Gadolinium-DTPA Complex: A Potential NMR Contrast Agent. American Roentgen Ray Society. 1984;142(3):619-624. https://doi.org/10.2214/ajr.142.3.619
- Martin Rohere, Hans Bauer. Comparison of Magnetic Properties of MRI Contrast Media Solutions at Different Magnetic Field Strengths. Investigative Radiology. 2005;11(40):715-724.
- H. S. Thomsen, S. K. Morcos. Radiographic Contast Media. BJU International. 2000;86(s1):1-10. https://doi.org/10.1046/j.1464-410X.2000.00092.x
- Lusic, Hrvoje, Mark W. Grinstaff. X-ray-computed tomography contrast agents. Chemical reviews. 2012;113(3):1641-1666. https://doi.org/10.1021/cr200358s
- Eva Llopis, Ernesto Fernandez. MR and CT Arthrography of the Hip. Semin Musculoskelet Radiol. 2012;16(1):42-56. https://doi.org/10.1055/s-0032-1304300