Preparation of photo-crosslinkable silk sericin hydrogel

  • Kim, Jung Eun (Department of Biosystems & Biomaterials Science and Engineering, Seoul National University) ;
  • Kim, Eui Hwa (Department of Textile Materials Engineering, Shinhan University) ;
  • Lee, Ki Hoon (Department of Biosystems & Biomaterials Science and Engineering, Seoul National University)
  • Received : 2017.12.14
  • Accepted : 2018.02.05
  • Published : 2018.03.31


A photo-crosslinkable sericin hydrogel has been prepared by introducing methacrylate groups on sericin. Lysine was the amino acid for methacrylation and the degree of methacrylation was increased with the amount of methacrylic anhydride added. When the concentration of methacrylic anhydride was 20% of sericin, 0.635 mmol/g of methacrylate group could be introduced. The storage modulus of sericin hydrogel was increased proportionally with the degree of methacrylation. However, the swelling ratio of sericin hydrogel decreased with the increase of methacrylation.


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Fig. 1. Reaction scheme of SS and methacrylic anhydride.

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Fig. 2. H-NMR spectra of SS and SS-MA15.

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Fig. 3. Effect of SS-MA15 concentration on the gelation behavior.

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Fig. 4. Storage modulus of SS-MA hydrogel.

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Fig. 5. Swelling ratio of SS-MA hydrogel

Table 1. Degree of methacrylation of SS-MA samples

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Grant : Development of 3D textile embedded hydrogel composite for articular cartilage repair

Supported by : Ministry of Trade, Industry & Energy (MOTIE)


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