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Regulation of Hippo signaling by actin remodeling

  • Seo, Jimyung (Graduate School of Medical Science and Engineering, KAIST) ;
  • Kim, Joon (Graduate School of Medical Science and Engineering, KAIST)
  • Received : 2017.12.21
  • Published : 2018.03.31

Abstract

The Hippo signaling pathway controls nuclear accumulation and stability of the transcriptional coregulator YAP and its paralog TAZ. The activity of Hippo-YAP signaling is influenced not only by biochemical signals, but also by cell shape and mechanical tension transmitted through cell-cell junctions and cell-matrix adhesions. Data accumulated thus far indicates that the actin cytoskeleton is a key mediator of the regulation of Hippo-YAP signaling by means of a variety of biochemical and mechanical cues. In this review, we have outlined the role of actin dynamics and actin-associated proteins in the regulation of Hippo-YAP signaling. In addition, we discuss actin-mediated regulation of YAP/TAZ activity independent of the core Hippo kinases MST and LATS. Although our understanding of the link between Hippo-YAP signaling and the actin cytoskeleton is progressing rapidly, many open questions remain.

Keywords

Actin;Hippo;Mechanotransduction;TAZ;YAP

Acknowledgement

Supported by : Korean National Research Foundation

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