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DNA binding partners of YAP/TAZ

  • Kim, Min-Kyu (Department of Biochemistry, College of Medicine, and Institute for Tumor Research, Chungbuk National University) ;
  • Jang, Ju-Won (Department of Biochemistry, College of Medicine, and Institute for Tumor Research, Chungbuk National University) ;
  • Bae, Suk-Chul (Department of Biochemistry, College of Medicine, and Institute for Tumor Research, Chungbuk National University)
  • Received : 2017.12.20
  • Published : 2018.03.31

Abstract

Hippo signaling plays critical roles in regulation of tissue homeostasis, organ size, and tumorigenesis by inhibiting YES-associated protein (YAP) and PDZ-binding protein TAZ through MST1/2 and LATS1/2 pathway. It is also engaged in cross-talk with various other signaling pathways, including WNT, BMPs, Notch, GPCRs, and Hedgehog to further modulate activities of YAP/TAZ. Because YAP and TAZ are transcriptional coactivators that lack DNA-binding activity, both proteins must interact with DNA-binding transcription factors to regulate target gene's expression. To activate target genes involved in cell proliferation, TEAD family members are major DNA-binding partners of YAP/TAZ. Accordingly, YAP/TAZ were originally classified as oncogenes. However, YAP might also play tumor-suppressing role. For example, YAP can bind to DNA-binding tumor suppressors including RUNXs and p73. Thus, YAP might act either as an oncogene or tumor suppressor depending on its binding partners. Here, we summarize roles of YAP depending on its DNA-binding partners and discuss context-dependent functions of YAP/TAZ.

Keywords

LATS1/2;MST1/2;RUNX;TAZ;TEAD;YAP

Acknowledgement

Supported by : National Research Foundation (NRF) of Korea

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