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The Interface Between ER and Mitochondria: Molecular Compositions and Functions

  • Lee, Soyeon ;
  • Min, Kyung-Tai
  • Received : 2018.11.29
  • Accepted : 2018.12.09
  • Published : 2018.12.31

Abstract

Mitochondria and endoplasmic reticulum (ER) are essential organelles in eukaryotic cells, which play key roles in various biological pathways. Mitochondria are responsible for ATP production, maintenance of $Ca^{2+}$ homeostasis and regulation of apoptosis, while ER is involved in protein folding, lipid metabolism as well as $Ca^{2+}$ homeostasis. These organelles have their own functions, but they also communicate via mitochondrial-associated ER membrane (MAM) to provide another level of regulations in energy production, lipid process, $Ca^{2+}$ buffering, and apoptosis. Hence, defects in MAM alter cell survival and death. Here, we review components forming the molecular junctions of MAM and how MAM regulates cellular functions. Furthermore, we discuss the effects of impaired ER-mitochondrial communication in various neurodegenerative diseases.

Keywords

ER-mitochondria tethering;mitochondrial-associated ER membrane (MAM);neurodegenerative disease

E1BJB7_2018_v41n12_1000_f0001.png 이미지

Fig 1. Composition of ER-mitochondria interface.

Table 1. List of protein components involved in MAM

E1BJB7_2018_v41n12_1000_t0001.png 이미지

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Acknowledgement

Supported by : National Research Foundation of Korea (NRF)