이팝나무 꽃에서 분리한 페놀 화합물의 생리활성 효소 억제효과

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이은호;조영제
Lee, Eun-Ho;Cho, Young-Je

  • 투고 : 2017.12.18
  • 심사 : 2018.02.20
  • 발행 : 2018.02.28

초록

이팝나무 꽃으로부터 phenolic 화합물을 추출하기 위하여 열수와 90% 에탄올로 phenolic compounds를 추출하였다. Xanthine oxidase 저해 효과를 측정한 결과, 열수와 에탄올 추출물 $200{\mu}g/mL$ phenolics 농도에서 각각 25.60, 15.92%의 저해 효과를 나타내었다. ${\alpha}$-Glucosidase 저해 효과를 측정한 결과 $200{\mu}g/mL$ phenolics 농도의 에탄올 추출물에서 100.00%의 매우 높은 저해 효과를 나타내었다. 미백효과를 측정하는 tyrosinase 저해 효과를 측정한 결과, 열수와 에탄올 추출물 $200{\mu}g/mL$ phenolics 농도에서 각각 17.27, 36.13%의 저해 효과를 나타내었다. 주름개선 효과를 측정하는 collagenase, elastase 저해 효과를 측정한 결과 에탄올 추출물에서는 $200{\mu}g/mL$ phenolics 농도에서 각각 96.26, 35.93%의 저해 효과를 나타내었다. 항염증 효과를 측정하는 hyaluronidase 저해 효과를 측정한 결과, 열수와 에탄올 추출물 $200{\mu}g/mL$ phenolics 농도에서 각각 36.96, 88.70%의 저해 효과를 나타내었다. 따라서 이팝나무 꽃에서 분리된 phenolic compounds는 $50-200{\mu}g/mL$ phenolics 농도 범위에서 항통풍, 당분해 억제, 미백, 주름개선 및 항염증과 관련된 생리활성 효소를 농도 의존적으로 유의하게 저해하는 것을 확인하였고, 이를 이용한 건강기능성 식품 및 미용식품의 기능성 소재로 활용 가능하다고 판단되었다.

키워드

biological activities;Chionanthus retusus flower;isolation;phenolic compounds

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