불등풀가사리 다당류의 분자량에 따른 면역증강 효과

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이대훈;홍주헌
Lee, Dae-Hoon;Hong, Joo-Heon

  • 투고 : 2018.01.17
  • 심사 : 2018.02.23
  • 발행 : 2018.02.28

초록

본 연구에서는 불등풀가사리(홍조류) 다당류를 기능성 소재로의 활용 가능성을 확인하기 위하여 분자량이 다른 다당류 3종을 제조하여 다양한 면역증강 효과를 확인하였다. GPA-III(${\geq}100kDa$)는 nitric oxide 및 cytokine(TNF-a 및 IL-6)분석에서 농도 유의적으로 함량이 증가하였으며, RT-PCR 분석을 통한 유전자 발현에서 iNOS 및 COX-2에서 높은 발현을 유도하여 면역증강 효과를 확인하였다. 따라서, GPA-III는 기능성식품 및 의약품의 잠재적 응용 가능성을 가지는 면역 증강제임을 나타내었다.

키워드

Gloiopeltis furcata;polysaccharides;immune-enhancing;nitric oxide;cytokine production

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