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Involvement of a Gr2a-Expressing Drosophila Pharyngeal Gustatory Receptor Neuron in Regulation of Aversion to High-Salt Foods

  • Kim, Haein (Department of Biological Sciences, Sungkyunkwan University) ;
  • Jeong, Yong Taek (Department of Oral Biology, BK21 PLUS Project, Yonsei University College of Dentistry) ;
  • Choi, Min Sung (Department of Biological Sciences, Sungkyunkwan University) ;
  • Choi, Jaekyun (Department of Biological Sciences, Sungkyunkwan University) ;
  • Moon, Seok Jun (Department of Oral Biology, BK21 PLUS Project, Yonsei University College of Dentistry) ;
  • Kwon, Jae Young (Department of Biological Sciences, Sungkyunkwan University)
  • Received : 2017.02.23
  • Accepted : 2017.04.18
  • Published : 2017.05.31

Abstract

Regulation of feeding is essential for animal survival. The pharyngeal sense organs can act as a second checkpoint of food quality, due to their position between external taste organs such as the labellum which initially assess food quality, and the digestive tract. Growing evidence provides support that the pharyngeal sensory neurons regulate feeding, but much is still unknown. We found that a pair of gustatory receptor neurons in the LSO, a Drosophila adult pharyngeal organ which expresses four gustatory receptors, is involved in feeding inhibition in response to high concentrations of sodium ions. RNAi experiments and mutant analysis showed that the gustatory receptor Gr2a is necessary for this process. This feeding preference determined by whether a food source is perceived as appetizing or not is influenced by nutritional conditions, such that when the animal is hungry, the need for energy dominates over how appealing the food source is. Our results provide experimental evidence that factors involved in feeding function in a context-dependent manner.

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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