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The Expanding Significance of Inositol Polyphosphate Multikinase as a Signaling Hub

  • Kim, Eunha (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Ahn, Hyoungjoon (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Kim, Min Gyu (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Lee, Haein (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Kim, Seyun (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST))
  • Received : 2017.04.26
  • Accepted : 2017.05.17
  • Published : 2017.05.31

Abstract

The inositol polyphosphates are a group of multifunctional signaling metabolites whose synthesis is catalyzed by a family of inositol kinases that are evolutionarily conserved from yeast to humans. Inositol polyphosphate multikinase (IPMK) was first identified as a subunit of the arginine-responsive transcription complex in budding yeast. In addition to its role in the production of inositol tetrakis- and pentakisphosphates ($IP_4$ and $IP_5$), IPMK also exhibits phosphatidylinositol 3-kinase (PI3-kinase) activity. Through its PI3-kinase activity, IPMK activates Akt/PKB and its downstream signaling pathways. IPMK also regulates several protein targets non-catalytically via protein-protein interactions. These non-catalytic targets include cytosolic signaling factors and transcription factors in the nucleus. In this review, we highlight the many known functions of mammalian IPMK in controlling cellular signaling networks and discuss future challenges related to clarifying the unknown roles IPMK plays in physiology and disease.

Acknowledgement

Supported by : National Research Foundation of Korea

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