Genetic effects of sterol regulatory element binding proteins and fatty acid-binding protein4 on the fatty acid composition of Korean cattle (Hanwoo)

  • Oh, Dong-Yep (Livestock Research institute) ;
  • Lee, Jea-Young (Department of Statistics, Yeungnam University) ;
  • Jang, Ji-Eun (Department of Statistics, Yeungnam University) ;
  • Lee, Seung-Uk (Department of Civil and Environmental Engineering, National University of Singapore)
  • Received : 2016.04.04
  • Accepted : 2016.08.03
  • Published : 2017.02.01


Objective: This study identifies single-nucleotide polymorphisms (SNP) or gene combinations that affect the flavor and quality of Korean cattle (Hanwoo) by using the SNP Harvester method. Methods: Four economic traits (oleic acid [C18:1], saturated fatty acids), monounsaturated fatty acids, and marbling score) were adjusted for environmental factors in order to focus solely on genetic effects. The SNP Harvester method was used to investigate gene combinations (two-way gene interactions) associated with these economic traits. Further, a multifactor dimensionality reduction method was used to identify superior genotypes in gene combinations. Results: Table 3 to 4 show the analysis results for differences between superior genotypes and others for selected major gene combinations using the multifactor dimensionality reduction method. Environmental factors were adjusted for in order to evaluate only the genetic effect. Table 5 shows the adjustment effect by comparing the accuracy before and after correction in two-way gene interactions. Conclusion: The g.3977-325 T>C and (g.2988 A>G, g.3977-325 T>C) combinations of fatty acid-binding protein4 were the superior gene, and the superior genotype combinations across all economic traits were the CC genotype at g.3977-325 T>C and the AACC, GACC, GGCC genotypes of (g.2988 A>G, g.3977-325 T>C).


Fatty Acid-binding Protein4 (FABP4);Single-Nucleotide Polymorphism (SNP);SNP Harvester;Sterol Regulatory Element Binding Proteins (SREBPs);Hanwoo


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