DOI QR코드

DOI QR Code

Chicken Egg Yolk Antibodies (IgY) for Prophylaxis and Treatment of Rotavirus Diarrhea in Human and Animal Neonates: A Concise Review

  • Thu, Hlaing Myat (Department of Medical Research) ;
  • Myat, Theingi Win (Department of Medical Research) ;
  • Win, Mo Mo (Department of Medical Research) ;
  • Thant, Kyaw Zin (Department of Medical Research) ;
  • Rahman, Shofiqur (Immunology Research Institute in Gifu, EW Nutrition Japan) ;
  • Umeda, Kouji (Immunology Research Institute in Gifu, EW Nutrition Japan) ;
  • Nguyen, Sa Van (Immunology Research Institute in Gifu, EW Nutrition Japan) ;
  • Icatlo, Faustino C. Jr. (Immunology Research Institute in Gifu, EW Nutrition Japan) ;
  • Higo-Moriguchi, Kyoko (Department of Virology and Parasitology, Fujita Health University School of Medicin) ;
  • Taniguchi, Koki (Department of Virology and Parasitology, Fujita Health University School of Medicin) ;
  • Tsuji, Takao (Department of Microbiology, Fujita Health University School of Medicine) ;
  • Oguma, Keiji (Department of Bacteriology, Okayama University Graduate School of Medicine) ;
  • Kim, Sang Jong (Dairy Team, Lotte R&D Center) ;
  • Bae, Hyun Suk (Dairy Team, Lotte R&D Center) ;
  • Choi, Hyuk Joon (BK bio)
  • Received : 2017.01.25
  • Accepted : 2017.02.16
  • Published : 2017.02.28

Abstract

The rotavirus-induced diarrhea of human and animal neonates is a major public health concern worldwide. Until recently, no effective therapy is available to specifically inactivate the rotavirion particles within the gut. Passive immunotherapy by oral administration of chicken egg yolk antibody (IgY) has emerged of late as a fresh alternative strategy to control infectious diseases of the alimentary tract and has been applied in the treatment of diarrhea due to rotavirus infection. The purpose of this concise review is to evaluate evidence on the properties and performance of anti-rotavirus immunoglobulin Y (IgY) for prevention and treatment of rotavirus diarrhea in human and animal neonates. A survey of relevant anti-rotavirus IgY basic studies and clinical trials among neonatal animals (since 1994-2015) and humans (since 1982-2015) have been reviewed and briefly summarized. Our analysis of a number of rotavirus investigations involving animal and human clinical trials revealed that anti-rotavirus IgY significantly reduced the severity of clinical manifestation of diarrhea among IgY-treated subjects relative to a corresponding control or placebo group. The accumulated information as a whole depicts oral IgY to be a safe and efficacious option for treatment of rotavirus diarrhea in neonates. There is however a clear need for more randomized, placebo controlled and double-blind trials with bigger sample size to further solidify and confirm claims of efficacy and safety in controlling diarrhea caused by rotavirus infection especially among human infants with health issues such as low birth weights or compromised immunity in whom it is most needed.

Keywords

References

  1. Arimitsu, H., Sasaki, K., Kohda, T., Shimizu, T., and Tsuji, T. (2014) Evaluation of Shiga toxin 2e-specific chicken egg yolk immunoglobulin: Production and neutralization activity. Microbiol. Immunol. 58, 643-648. https://doi.org/10.1111/1348-0421.12197
  2. Barnes, G. L., Hewson, P. H., Mclellan, J. A., Doyle, L. W., Knoches, A. M. L., and Kitchen,W. H. (1982) A randomised trial of oral gammaglobulin in low-birth-weight infants infected with rotavirus. The Lancet. 319, 1371-1373. https://doi.org/10.1016/S0140-6736(82)92496-5
  3. Baumler, A. J. and Sperandio, V. (2016) Interactions between the microbiota and pathogenic bacteria in the gut. Nature 535, 85-93. https://doi.org/10.1038/nature18849
  4. Bhavnani, D., Goldstick, J. E., Cevallos, W., Trueba, G., and Eisenberg, J. N. S. (2012) Synergistic effects between rotavirus and coinfecting pathogens on diarrheal disease: Evidence from a community-based study in Northwestern Ecuador. Am. J. Epidemiol. 176, 387-395. https://doi.org/10.1093/aje/kws220
  5. Dai, Y. C., Wang, Y. Y., Zhang, X. F., Tan, M., Xia, M., Wu, X. B., Jiang, X., and Nie, J. (2012) Evaluation of anti-norovirus IgY from egg yolk of chickens immunized with norovirus P particles. J. Virol. Methods 186, 126-131. https://doi.org/10.1016/j.jviromet.2012.07.002
  6. Dhama, K., Chauhan, R. S., Mahendran, M., and Malik, S. V. S. (2009) Rotavirus diarrhea in bovines and other domesticated animals. Vet. Res. Comm. 33, 1-23.
  7. Diraviyam, T., Zhao, B., Wang, Y., Schade, R., Michael A., and Zhang, X. (2014) Effect of chicken egg yolk antibodies (IgY) against diarrhea in domesticated animals: A systematic review and meta-analysis. PLoS ONE 9, e97716. https://doi.org/10.1371/journal.pone.0097716
  8. Gujral, N., Löbenberg, R., Suresh, M., and Sunwoo, H. (2012) In vitro and in vivo binding activity of chicken egg yolk immunoglobulin Y (IgY) against gliadin in food matrix. J. Agric. Food Chem. 60, 3166-3172. https://doi.org/10.1021/jf205319s
  9. Hatta, H., Tsuda, K., Akachi, S., Kim, M., Yamamoto, T., and Ebina, T. (1993) Oral passive immunization effect of antihuman rotavirus IgY and its behavior against proteolytic enzymes. Biosci. Biotechnol. Biochem. 57, 1077-1081.
  10. Hirai, K., Arimitsu, H., Umeda, K., Yokota, K., Shen, L., Ayada, K., Kodama, Y., Tsuji, T., Hirai, Y., and Oguma, K. (2010) Passive oral immunization by egg yolk immunoglobulin (IgY) to Vibrio cholerae effectively prevents cholera. Acta Med. Okayama. 64, 163-170.
  11. Hirose, M., Ando, T., Shofiqur R., Umeda K., Kodama Y., Nguyen S. V., Goto, T., Shimada, M., and Nagaoka, S. (2013) Anti-obesity activity of hen egg anti-lipase immunoglobulin yolk, a novel pancreatic lipase inhibitor. Nutr. Metab. (Lond). 10, 70. https://doi.org/10.1186/1743-7075-10-70
  12. Hlaing, M. T., Theingi, W. M., Mo Mo, W., Kyaw, Z. T., Rahman, S., Umeda, K., Nguyen, V. S., Icatlo, F. C., Jr., Moriguchi, K. H., Taniguchi, K., Tsuji. T., and Oguma, K. (2015). Immunoglobulin Y-fortified infant milk formula as adjunct to treatment of diarrhea among rotavirus-infected hospitalized children in Myanmar: a randomized, double-blind, placebo-controlled trial. Unpublished data.
  13. Ibrahim, El-S. M., Rahman, A. K. M. S., Isoda, R., Umeda, K., van Sa, N., and Kodama Y. (2008) In vitro and in vivo effectiveness of egg yolk antibody against Candida albicans (anti-CA IgY). Vaccine 26, 2073-2080. https://doi.org/10.1016/j.vaccine.2008.02.046
  14. Ikemori, Y, Peralta, R.C., Kuroki, M., Yokoyama, H., and Kodama Y. (1993) Avidity of chicken yolk antibodies to enterotoxigenic Escherichia coli fimbriae. Poult Sci. 72, 2361-2365. https://doi.org/10.3382/ps.0722361
  15. Ikemori, Y., Ohta, M., Umeda, K., Peralta, R. C., Kuroki, M., Yokoyama, H., and Kodama, Y. (1996) Passage of chicken egg yolk antibody treated with hydroxypropyl methylcellulose phthalate in the gastrointestinal tract of calves. J. Vet. Med. Sci. 58, 365-367. https://doi.org/10.1292/jvms.58.365
  16. Kollberg, H. (2015) Avian antibodies (IgY) to fight antibiotic resistance. Clin. Microbiol. 4, 2. 1000194.
  17. Lee, C. H., Lee, Y. C., Liang, M. H., Leu, S. J., Lin, L. T., Chiang, J. R., and Yang, Y. Y. (2015) Antibodies against venom of the snake Deinagkistrodon acutus. Appl. Environ. Microbiol. 82, 71-80.
  18. Lee, K. E., Han, B. K., Han, J. Y., Hong, J. Y., Kim, M. N., Heo, W. I., Sohn, M. H., Kim, K. W., and Kim, K. E. (2014) Production of egg yolk antibodies specific to house dust mite proteins. Yonsei Med. J. 55, 999-1004.
  19. Li, X. Y., Jin, L. J., Uzonna, J. E., Li, S. Y., Liu, J. J., Li, H. Q., Lu, Y. N., Zhen, Y. H., and Xu, Y. P. (2009) Chitosan-alginate microcapsules for oral delivery of egg yolk immunoglobulin (IgY): In vivo evaluation in a pig model of enteric colibacillosis. Vet. Immunol. Immunopathol. 129, 132-136. https://doi.org/10.1016/j.vetimm.2008.12.016
  20. Müller, S., Schubert, A., Zajac, J., Dyck, T., and Oelkrug, C. (2015) IgY antibodies in human nutrition for disease prevention. Nutr. J. 14, 109.
  21. Neri, P., Tokoro, S., Sugiyama, T., Umeda, K., Shimizu, T., Tsuji, T., Kodama Y., and Mori, H. (2012) Recombinant Shiga toxin B subunit can induce neutralizing immunoglobulin Y antibody. Biol. Pharm. Bull. 35, 917-923. https://doi.org/10.1248/bpb.35.917
  22. Nilsson, E., Larsson, A., Olesen, H.V., Wejåker, P. E., and Kollberg, H. (2008) Good effect of IgY against Pseudomonas aeruginosa infections in cystic fibrosis patients. Pediatr Pulmonol. 43, 892-899. https://doi.org/10.1002/ppul.20875
  23. Nguyen, H. H., Tumpey, T. M., Park, H. J., Byun, Y. H., Tran, L. D., Nguyen, V. D., Kilgore, P. E., Czerkinsky, C., Katz, J. M., Seong, B. L., Song, J. M., Kim, Y. B., Do, H. T., Nguyen,T., and Nguyen, C. V. (2010) Prophylactic and therapeutic efficacy of avian antibodies against influenza virus H5N1 and H1N1 in mice. PLoS ONE. 5, e10152.
  24. Nguyen, S. V., Icatlo, Jr. F. C., Nakano, T., Isogai, E., Hirose, K., Mizugai, H., Kobayashi-Sakamoto, M., Isogai, H., and Chiba, I. (2011) Anti cell-associated glucosyltransferase immunoglobulin Y suppression of salivary mutans streptococciin healthy young adults. J. Ame. Dent. Assoc. 142, 943-949. https://doi.org/10.14219/jada.archive.2011.0301
  25. Pammi, M. and Haque, K. N. (2011) Oral immunoglobulin for the treatment of rotavirus diarrhea in low birth weight infants. Cochrane Database Syst. Rev. 5.
  26. Parr, R. D., Storey, S. M., Mitchell, D. M., McIntosh, A. L., Zhou, M., Mir, K. D., and Ball, J. M. (2006) The rotavirus enterotoxin NSP4 directly interacts with the caveolar structuralprotein caveolin-1. J. Virol. 80, 2842-2854. https://doi.org/10.1128/JVI.80.6.2842-2854.2006
  27. Raffatellu, M. and Baumler, A. J. (2010) Salmonella's iron armor for battling the host and its microbiota. Gut Microbes. 1,70-72. https://doi.org/10.4161/gmic.1.1.10951
  28. Rahman, S., Higo-Moriguchi, K., Htun, K. W., Taniguchi, K., Icatlo, F. C., Jr., Tsuji, T., Kodama, Y., van Nguyen, S., Umeda, K., Oo, H. N., Myint, Y. Y., Htut, T., Myint, S. S., Thura, K., Thu, H. M., Fatmawati, N. N., and Oguma, K. (2012) Randomized placebo-controlled clinical trial of immunoglobulin Y as adjunct to standard supportive therapy for rotavirus-associated diarrhea among pediatric patients. Vaccine 30, 4661-4669. https://doi.org/10.1016/j.vaccine.2012.04.091
  29. Rahman, S., Nguyen, S., Icatlo, F., Umeda, K., and Kodama, Y. (2013a) Oral passive IgY-based immunotherapeutics: A novel solution for prevention and treatment of alimentary tract diseases. Hum. Vaccines Immunotherapeutics 9, 1039-1048.
  30. Rahman, S., Umeda, K., Icatlo, Jr. F. C., Lee, K. W., Kim, S. H., Choi, H. J., Han, B. K., Park, Y. S., and Sa, N. V. (2013b) In vitro cytoprotective effect of infant milk formula fortified with human rotavirus-specific hyperimmune yolk immunoglobulins (IgY). Food Sci. Biotechnol. 22, 1699-1705. https://doi.org/10.1007/s10068-013-0269-4
  31. Robert, F. R. (2004) Pathogenesis of intestinal and systemicrotavirus infection. J. Virol. 78, 10213-10220.
  32. Sarker, S. A., Casswall, T. H., Juneja, L. R., Hoq, E., Hossain, I., Fuchs, G. J., and Hammarström L. (2001) Randomized, placebo-controlled, clinical trial of hyperimmunized chicken egg yolk immunoglobulin in children with rotavirus diarrhea. J. Pediatr. Gastroenterol. Nutr. 32, 19-25. https://doi.org/10.1097/00005176-200101000-00009
  33. Selvan, K., Sentila, R., and Michael, A. (2012) Generation and characterization of chicken egg yolk antibodies against Propionibacterium acnes for the prevention of acne Vulgaris. Ind. J. Dermatol. 57, 15-19. https://doi.org/10.4103/0019-5154.92669
  34. Shin, J. H., Yang, M., Nam, S.W., Kim, J. T., Myung, N. H., Bang, W.G., and Roe, I. H. (2002) Use of egg yolk-derived immunoglobulin as an alternative to antibiotic treatment for control of Helicobacter pylori infection. Clin. Diagn. Lab. Immunol. 9, 1061-1066.
  35. Suzuki, H., Nomura, S., Masaoka, T., Goshima, H., Kamata, N., Kodama Y, Ishii, H., Kitajima, M., Nomoto, K., and Hibi, T. (2004) Effect of dietary anti-Helicobacter pylori-urease immunoglobulin Y on Helicobacter pylori infection. Aliment Pharmacol. Therapeut. 20, 185-192. https://doi.org/10.1111/j.1365-2036.2004.02027.x
  36. Vega, C., Bok, M., Saif, L., Fernandez, F., and Parreno, V. (2015) Egg yolk IgY antibodies: A therapeutic intervention against group A rotavirus in calves. Res. Vet. Sci. 103, 1-10. https://doi.org/10.1016/j.rvsc.2015.09.005
  37. Yokoyama, H., Peralta, R. C., Sendo, S., Ikemori, Y., and Kodama, Y. (1993) Detection of passage and absorption of chicken egg yolk immunoglobulins in the gastrointestinal tract of pigs by use of enzyme-linked immunosorbent assay and fluorescent antibody testing. Am. J. Vet. Res. 54, 867-872.
  38. Yokoyama, K., Sugano, N., Shimada, T., Shofiqur, R. A., Ibrahim, El-S. M., Isoda, R., Umeda, K., van Sa, N., Kodama,Y., and Ito, K. (2007) Effects of egg yolk antibody against Porphyromonas gingivalis gingipains in periodontitis patients. J. Oral Sci. 49, 201-206. https://doi.org/10.2334/josnusd.49.201

Cited by

  1. Drug development and acute gastrointestinal infections vol.27, pp.3, 2018, https://doi.org/10.1080/13543784.2018.1420779
  2. Application of Ostrich Antibodies to the Restoration of Hair Growth, a Preliminary and Case Report vol.08, pp.04, 2018, https://doi.org/10.4236/jcdsa.2018.84019
  3. IgY antibodies for the immunoprophylaxis and therapy of respiratory infections pp.2164-554X, 2018, https://doi.org/10.1080/21645515.2018.1514224
  4. Use of chicken immunoglobulin Y in general virology vol.39, pp.3, 2018, https://doi.org/10.1080/15321819.2018.1500375