SR Proteins: Binders, Regulators, and Connectors of RNA

  • Jeong, Sunjoo (Department of Bioconvergent Science and Technology, Dankook University)
  • Received : 2016.12.30
  • Accepted : 2017.01.06
  • Published : 2017.01.31


Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as constitutive and alternative splicing regulators. As splicing is linked to transcriptional and post-transcriptional steps, SR proteins are implicated in the regulation of multiple aspects of the gene expression program. Recent global analyses of SR-RNA interaction maps have advanced our understanding of SR-regulated gene expression. Diverse SR proteins play partially overlapping but distinct roles in transcription-coupled splicing and mRNA processing in the nucleus. In addition, shuttling SR proteins act as adaptors for mRNA export and as regulators for translation in the cytoplasm. This mini-review will summarize the roles of SR proteins as RNA binders, regulators, and connectors from transcription in the nucleus to translation in the cytoplasm.


export;RNA-binding proteins;SR proteins;splicing;transcription;translation


Supported by : Dankook University


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