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Oily Fish Consumption Modifies the Association between CD36 rs6969989 Polymorphism and Lipid Profiles in Korean Women

  • Shin, Yoonjin (Department of Nutritional Science and Food Management, Ewha Womans University) ;
  • Kim, Yangha (Department of Nutritional Science and Food Management, Ewha Womans University)
  • Received : 2016.06.29
  • Accepted : 2016.08.23
  • Published : 2016.09.30

Abstract

The aim of this study was to investigate the association of CD36, a class B scavenger receptor, rs6969989 polymorphism with the serum lipid profiles in Korean women, together with their modulation by oily fish consumption. Subjects were participants from the Korean Genome Epidemiology Study (KoGES), which was initiated in 2001 as a large-scale. A total of 4,210 women aged 39 to 70 were included in this study. Data were collected using self-administered questionnaires, anthropometric measurements, and blood chemical analysis. Dietary intake was analyzed using a semi-quantitative food frequency questionnaire. The minor allele frequency for rs6969989 was found in 12% of this population. Homozygotes minor G allele at the rs6868989 exhibited significantly higher high density lipoprotein cholesterol (HDLC) concentrations (P-trend=0.043) and lower fasting glucose (P-trend=0.013) than major allele A carriers. The risk of low HDL-C was significantly lower in homozygotes for the G allele than the A allele carriers (P-trend=0.032). Gene-diet interaction effects between rs6969989 and oily fish intake were significantly associated with the risk of dyslipidemia (P-interaction=0.004). Subjects with homozygotes minor G allele and high oily fish intake generally had a lower risk of dyslipidemia than did those with major allele homozygotes and low oily fish intake. These findings supported that oily fish consumption may modulate the contributions of CD36 rs6969989 on genetic predisposition to the risk of dyslipidemia.

Acknowledgement

Supported by : Centers for Disease Control and Prevention, National Research Foundation of Korea (NRF)

References

  1. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). 2002. Third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 106: 3143-3421.
  2. Anderson KM, Castelli WP, Levy D. 1987. Cholesterol and mortality: 30 years of follow-up from the Framingham study. JAMA 257: 2176-2180. https://doi.org/10.1001/jama.1987.03390160062027
  3. Calder PC. 2004. n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored. Clin Sci 107: 1-11. https://doi.org/10.1042/CS20040119
  4. Carrero JJ, Grimble RF. 2006. Does nutrition have a role in peripheral vascular disease?. Br J Nutr 95: 217-229. https://doi.org/10.1079/BJN20051616
  5. Kris-Etherton PM, Harris WS, Appel LJ; American Heart Association. Nutrition Committee. 2002. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106: 2747-2757. https://doi.org/10.1161/01.CIR.0000038493.65177.94
  6. Harris WS. 1997. n-3 fatty acids and serum lipoproteins: human studies. Am J Clin Nutr 65: 1645S-1654S. https://doi.org/10.1093/ajcn/65.5.1645S
  7. Febbraio M, Hajjar DP, Silverstein RL. 2001. CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism. J Clin Invest 108: 785-791. https://doi.org/10.1172/JCI14006
  8. Hajri T, Abumrad NA. 2002. Fatty acid transport across membranes: relevance to nutrition and metabolic pathology. Annu Rev Nutr 22: 383-415. https://doi.org/10.1146/annurev.nutr.22.020402.130846
  9. Aitman TJ, Glazier AM, Wallace CA, Cooper LD, Norsworthy PJ, Wahid FN, Al-Majali KM, Trembling PM, Mann CJ, Shoulders CC, Graf D, St Lezin E, Kurtz TW, Kren V, Pravenec M, Ibrahimi A, Abumrad NA, Stanton LW, Scott J. 1999. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet 21: 76-83. https://doi.org/10.1038/5013
  10. Febbraio M, Abumrad NA, Hajjar DP, Sharma K, Cheng W, Pearce SF, Silverstein RL. 1999. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J Biol Chem 274: 19055-19062. https://doi.org/10.1074/jbc.274.27.19055
  11. Tanaka T, Nakata T, Oka T, Ogawa T, Okamoto F, Kusaka Y, Sohmiya K, Shimamoto K, Itakura K. 2001. Defect in human myocardial long-chain fatty acid uptake is caused by FAT/CD36 mutations. J Lipid Res 42: 751-759.
  12. Nozaki S, Tanaka T, Yamashita S, Sohmiya K, Yoshizumi T, Okamoto F, Kitaura Y, Kotake C, Nishida H, Nakata A, Nakagawa T, Matsumoto K, Kameda-Takemura K, Tadokoro S, Kurata Y, Tomiyama Y, Kawamura K, Matsuzawa Y. 1999. CD36 mediates long-chain fatty acid transport in human myocardium: complete myocardial accumulation defect of radiolabeled long-chain fatty acid analog in subjects with CD36 deficiency. Mol Cell Biochem 192: 129-135. https://doi.org/10.1023/A:1006816702425
  13. Chien KL, Hsu HC, Liu PH, Lin HJ, Chen MF. 2012. Common sequence variants in CD36 gene and the levels of triglyceride and high-density lipoprotein cholesterol among ethnic Chinese in Taiwan. Lipids Health Dis 11: 174. https://doi.org/10.1186/1476-511X-11-174
  14. Ramos-Arellano LE, Salgado-Bernabe AB, Guzman-Guzman IP, Salgado-Goytia L, Munoz-Valle JF, Parra-Rojas I. 2013. CD36 haplotypes are associated with lipid profile in normal-weight subjects. Lipids Health Dis 12: 167. https://doi.org/10.1186/1476-511X-12-167
  15. Lim S, Jang HC, Lee HK, Kimm KC, Park C, Cho NH. 2006. A rural-urban comparison of the characteristics of the metabolic syndrome by gender in Korea: The Korean Health and Genome Study (KHGS). J Endocrinol Invest 29: 313-319. https://doi.org/10.1007/BF03344102
  16. Friedewald WT, Levy RI, Fredrickson DS. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-502.
  17. Committee for Establishing Treatment Instruction for Dyslipidemia of the Korean Society of Lipidology and Atherosclerosis. 2009. Treatment instruction for dyslipidemia. 2nd ed. Korean Society of Lipidology and Atherosclerosis, Seoul, Korea. p 33.
  18. Ahn Y, Lee JE, Paik HY, Lee HK, Jo I, Kimm K. 2003. Development of a semi-quantitative food frequency questionnaire based on dietary data from the Korea National Health and Nutrition Examination Survey. Nutr Sci 6: 173-184.
  19. Ahn Y, Lee JE, Cho NH, Shin C, Park C, Oh BS, Kimm K. 2004. Validation and calibration of semi-quantitative food frequency questionnaire -with participants of the Korean Health and Genome Study-. Korean J Community Nutr 9: 173-182.
  20. KNS. 2000. Recommended dietary allowances for Koreans. 7th ed. The Korean Nutrition Society, Seoul, Korea. p 259-464.
  21. Cho YS, Go MJ, Kim YJ, Heo JY, Oh JH, Ban HJ, Yoon D, Lee MH, Kim DJ, Park M, Cha SH, Kim JW, Han BG, Min H, Ahn Y, Park MS, Han HR, Jang HY, Cho EY, Lee JE, Cho NH, Shin C, Park T, Park JW, Lee JK, Cardon L, Clarke G, McCarthy MI, Lee JY, Lee JK, Oh B, Kim HL. 2009. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet 41: 527-534. https://doi.org/10.1038/ng.357
  22. Curtis BR, Aster RH. 1996. Incidence of the Nak(a)-negative platelet phenotype in African Americans is similar to that of Asians. Transfusion 36: 331-334. https://doi.org/10.1046/j.1537-2995.1996.36496226147.x
  23. Yamashita S, Hirano K, Kuwasako T, Janabi M, Toyama Y, Ishigami M, Sakai N. 2007. Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis; insights from CD36-deficient patients. Mol Cell Biochem 299: 19-22. https://doi.org/10.1007/s11010-005-9031-4
  24. Ayodo G, Price AL, Keinan A, Ajwang A, Otieno MF, Orago ASS, Patterson N, Reich D. 2007. Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants. Am J Hum Genet 81: 234-242. https://doi.org/10.1086/519221
  25. Sabeti PC, Schaffner SF, Fry B, Lohmueller J, Varilly P, Shamovsky O, Palma A, Mikkelsen TS, Altshuler D, Lander ES. 2006. Positive natural selection in the human lineage. Science 312: 1614-1620. https://doi.org/10.1126/science.1124309
  26. Love-Gregory L, Sherva R, Sun L, Wasson J, Schappe T, Doria A, Rao DC, Hunt SC, Klein S, Neuman RJ, Permutt MA, Abumrad NA. 2008. Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol. Hum Mol Genet 17: 1695-1704. https://doi.org/10.1093/hmg/ddn060
  27. Zhang L, Geng Y, Xiao N, Yin M, Mao L, Ren G, Zhang C, Liu P, Lu N, An L, Pan J. 2009. High dietary n-6/n-3 PUFA ratio promotes HDL cholesterol level, but does not suppress atherogenesis in apolipoprotein E-null mice 1. J Atheroscler Thromb 16: 463-471. https://doi.org/10.5551/jat.No1347
  28. Spady DK, Kearney DM, Hobbs HH. 1999. Polyunsaturated fatty acids up-regulate hepatic scavenger receptor B1 (SR-BI) expression and HDL cholesteryl ester uptake in the hamster. J Lipid Res 40: 1384-1394.
  29. Schmidt EB, Varming K, Ernst E, Madsen P, Dyerberg J. 1990. Dose-response studies on the effect of n-3 polyunsaturated fatty acids on lipids and haemostasis. Thromb Haemost 63: 1-5. https://doi.org/10.1055/s-0038-1645675
  30. Madden J, Carrero JJ, Brunner A, Dastur N, Shearman CP, Calder PC, Grimble RF. 2008. Polymorphisms in the CD36 gene modulate the ability of fish oil supplements to lower fasting plasma triacyl glycerol and raise HDL cholesterol concentrations in healthy middle-aged men. Prostaglandins Leukot Essent Fatty Acids 78: 327-335. https://doi.org/10.1016/j.plefa.2008.04.003
  31. Stampfer MJ, Hu FB, Manson JE, Rimm EB, Willett WC. 2000. Primary prevention of coronary heart disease in women through diet and lifestyle. N Engl J Med 343: 16-22. https://doi.org/10.1056/NEJM200007063430103

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