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Combined Detection of Serum IL-10, IL-17, and CXCL10 Predicts Acute Rejection Following Adult Liver Transplantation

  • Kim, Nayoung (Department of Convergence Medicine & Asan Institute for Life Sciences) ;
  • Yoon, Young-In (Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Yoo, Hyun Ju (Department of Convergence Medicine & Asan Institute for Life Sciences) ;
  • Tak, Eunyoung (Department of Convergence Medicine & Asan Institute for Life Sciences) ;
  • Ahn, Chul-Soo (Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Song, Gi-Won (Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Sung-Gyu (Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Hwang, Shin (Division of Liver Transplantation and Hepatobiliary Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine)
  • Received : 2016.05.26
  • Accepted : 2016.07.20
  • Published : 2016.08.31

Abstract

Discovery of non-invasive diagnostic and predictive biomarkers for acute rejection in liver transplant patients would help to ensure the preservation of liver function in the graft, eventually contributing to improved graft and patient survival. We evaluated selected cytokines and chemokines in the sera from liver transplant patients as potential biomarkers for acute rejection, and found that the combined detection of IL-10, IL-17, and CXCL10 at 1-2 weeks post-operation could predict acute rejection following adult liver transplantation with 97% specificity and 94% sensitivity.

Acknowledgement

Supported by : National Research Foundation of Korea (NRF), Asan Institute for Life Sciences, Asan Medical Center

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