DOI QR코드

DOI QR Code

Evaluation of Cholangiocarcinoma Risk and its Related Factors In Wetland Geographical Communities of Ubon Ratchathani, Thailand

  • Songserm, Nopparat (Department of Community Health, Faculty of Public Health, Ubon Ratchathani Rajabhat University) ;
  • Woradet, Somkiattiyos (Department of Public Health, Faculty of Health and Sports Science, Thaksin University) ;
  • Bureelerd, Onanong (Department of Community Health, Faculty of Public Health, Ubon Ratchathani Rajabhat University) ;
  • Charoenbut, Pattaraporn (Department of Community Health, Faculty of Public Health, Ubon Ratchathani Rajabhat University)
  • Published : 2016.06.01

Abstract

Wetland geographical areas have a higher incidence of Opisthorchis viverrini-associated cholangiocarcinoma (CCA), confirmed by data from geographic information systems, than other areas. Behavioral data also indicate that people in these areas traditionally eat uncooked freshwater fish dishes, a vehicle for O. viverrini infection. The best approach to reducing CCA incidence is decreasing risk factors together with behavior alteration. Evaluation of CCA risk and its related factors are first needed for planning the prevention and control programs in the future. We therefore aimed to evaluate the CCA risk and explore its related factors among people in wetland communities of Ubon Ratchathani, Thailand. A cross-sectional study was conducted between July and August 2014. In total 906 participants, with informed consent, completed questionnaires. Overall risk of CCA was determined by multiplying odds ratios (ORs) of the risk factors for CCA from literature reviews. A mean score of 5.95 was applied as the cut-off point. Assessment of factors related to overall risk of CCA was accomplished using conditional logistic regression. Of all participants, 60.15% had a high level of the overall risk of CCA. Factors related to the overall risk of CCA were gender (p<0.001), marital status (p<0.001), perceived susceptibility (p=0.043) and prevention behavior for CCA (p<0.001). In conclusion, most participants in this community had a high level of overall risk of CCA. Therefore, integrated prevention and control programs continue to be urgently required.

Keywords

Cholangiocarcinoma;risk factors;wetland community;Ubon Ratchathani;Thailand

Acknowledgement

Supported by : Ubon Ratchathani Rajabhat University

References

  1. Chalasani N, Baluyut A, Ismail A, et al (2000). Cholangiocarcinoma in patients with primary sclerosing cholangitis: a multicenter case-control study. Hepatol 31, 7-11. https://doi.org/10.1002/hep.510310103
  2. Elkins DB, Mairiang E, Sithithaworn P, et al (1996). Crosssectional patterns of hepatobiliary abnormalities and possible precursor conditions of cholangiocarcinoma associated with Opisthorchis viverrini infection in humans. Am J Trop Med Hyg, 55, 295-301. https://doi.org/10.4269/ajtmh.1996.55.295
  3. Grundy-Warr C, Andrews RH, SithithawornP, et al (2012). Raw attitudes, wetland cultures, life-styles: Socio-cultural dynamics relating to Opisthorchis viverrini in the Mekong basin. Parasitol Int, 61, 65-70. https://doi.org/10.1016/j.parint.2011.06.015
  4. Haswell-Elkins MR, Mairiang E, Mairiang P, et al (1994). Cross-sectional study of Opisthorchis viverrini infection and cholangiocarcinoma in communities within a high-risk area in northeast Thailand. Int J Cancer, 59, 505-9. https://doi.org/10.1002/ijc.2910590412
  5. Honjo S, Srivatanakul P, Sriplung H, et al (2005). Genetic and environmental determinants of risk for cholangiocarcinoma via Opisthorchis viverrini in a densely infested area in Nakhon Phanom, northeast Thailand. Int J Cancer, 117, 854-60. https://doi.org/10.1002/ijc.21146
  6. IARC (1994). Schistosomes, liver flukes and Helicobacter pylori. IARC Monogr Eval Carcinog Risks Hum, 61, 1-241.
  7. Imsamran W, Chaiwerawattana A, Wiangnon S, et al. Cancer in Thailand 2010-2012, vol. VIII. Bangkok: Bangkok Medical Publisher; 2015.
  8. Kamsa-ard S, Laopaiboon M, Luvira V, et al (2013). Association between praziquantel and cholangiocarcinoma in patients infected with Opisthorchis viverrini: a systematic review and meta-analysis. Asian Pac J Cancer Prev, 14, 7011-6. https://doi.org/10.7314/APJCP.2013.14.11.7011
  9. Manwong M, Songserm N, Promthet S, et al (2013). Risk factors for cholangiocarcinoma in the lower part of Northeast Thailand: a hospital-based case-control study. Asian Pac J Cancer Prev, 14, 5953-6. https://doi.org/10.7314/APJCP.2013.14.10.5953
  10. Poomphakwaen K, Promthet S, Kamsa-Ard S, et al (2009). Risk factors for cholangiocarcinoma in Khon Kaen, Thailand: a nested case- control study. Asian Pac J Cancer Prev, 10, 251-8.
  11. Shin HR, Lee CU, Park HJ, et al (1996). Hepatitis B and C virus, Clonorchis sinensis for the risk of liver cancer: a case-control study in Pusan, Korea. Int J Epidemiol, 25, 933-40. https://doi.org/10.1093/ije/25.5.933
  12. Sithithaworn P, Andrews RH, Van De N, et al (2012). The current status of opisthorchiasis and clonorchiasis in the Mekong Basin. Parasitol Int, 61, 10-6. https://doi.org/10.1016/j.parint.2011.08.014
  13. Songserm N, Bureelerd O, Thongprung S, et al (2005). Community participation in cholangiocarcinoma prevention in Ubon Ratchathani, Thailand: relations with age and health behavior. Asian Pac J Cancer Prev, 16, 7375-9.
  14. Songserm N, Promthet S, Sithithaworn P, et al (2011). MTHFR polymorphisms and Opisthorchis viverrini infection: a relationship with increased susceptibility to cholangiocarcinoma in Thailand. Asian Pac J Cancer Prev, 12, 1341-5.
  15. Songserm N, Promthet S, Sithithaworn P, et al (2012). Risk factors for cholangiocarcinoma in high-risk area of Thailand: role of lifestyle, diet and methylenetetrahydrofolate reductase polymorphisms. Cancer Epidemiol, 36, 89-94. https://doi.org/10.1016/j.canep.2011.04.005
  16. Sriamporn S, Pisani P, Pipitgool V, et al (2004). Prevalence of Opisthorchis viverrini infection and incidence of cholangiocarcinoma in Khon Kaen, Northeast Thailand. Trop Med Int Health, 9, 588-94. https://doi.org/10.1111/j.1365-3156.2004.01234.x
  17. Sripa B, Kaewkes S, Sithithaworn P, et al (2007). Liver fluke induces cholangiocarcinoma. PLoS Med, 4, 201. https://doi.org/10.1371/journal.pmed.0040201
  18. Vatanasapt V, Uttaravichien T, Mairiang E, et al (1990). Cholangiocarcinoma in north-east Thailand. Lancet, 335, 116-7.
  19. Wattanayingcharoenchai S, Nithikathkul C, Wonsaroj T, et al (2011). Geographic information system of Opisthorchis viverrini in northeast Thailand. Asian Biomedicine, 5, 687-91.