DOI QR코드

DOI QR Code

Survival in Head and Neck Cancers - Results of A Multi-Institution Study

  • Nandakumar, Ambakumar (Patterns of Cancer Care and Survival Studies Group, National Centre for Disease Informatics and Research, (ICMR))
  • Published : 2016.06.01

Abstract

Background: The prime output of Hospital Based Cancer Registries is stage and treatment based survival to evaluate patient care, but because of challenges of obtaining follow-up details a separate study on Patterns of Care and Survival for selected sites was initiated under the National Cancer Registry Programme of India. The results of stage and treatment based survival for head and neck cancers by individual organ sites are presented. Materials and Methods: A standardized Patient Information Form recorded the details and entered on-line at www.hbccrindia.org to a central repository - National Centre for Disease Informatics and Research. Cases from 12 institutions diagnosed between 1 January 2006 and 31 December 2008 comprised the study subjects. The patterns of treatment were examined for 14053 and survival for 4773 patients from five institutions who reported at least 70% follow-up as of 31 December 2012. Results: Surgical treatment with radiation for cancer tongue and mouth showed five year cumulative survival (FCS) of 67.5% and 60.4% respectively for locally advanced stage. Chemo-radiation compared to radiation alone showed better survival benefit of around 15% in both oro and hypo-pharyngeal cancers and their FCS was 40.0%; Hazard Ratio (HR):1.5;CI=1.2-1.9) and 38.7%; (HR):1.7; CI=1.3-2.2). Conclusions: The awareness about the requirement of concurrent chemo-radiation in specifically cancers of the oro and hypopharynx has to be promoted in developing countries. The annual (2014) estimate number of new Head and Neck cancers with locally advanced disease in India is around 140,000 and 91,000 (65%) patients do not receive the benefit of optimal treatment with ensuing poorer survival.

Keywords

NCDIR;informatics;multi-institutional;head and neck cancers;tongue;oral cancer;oropharynx

References

  1. Baykara M, Buyukberber S, Ozturk B, et al (2013). Efficacy and safety of concomitant chemoradiotherapy with cisplatin and docetaxel in patients with locally advanced squamous cell head and neck cancers. Asian Pac J Cancer Prev, 14, 2557-61. https://doi.org/10.7314/APJCP.2013.14.4.2557
  2. Cox DR (1972). Regression models and life-tables. J R Stat Soc [B], 34, 187-220.
  3. D'Cruz AK, Siddachari RC, Walvekar RR (2009). Elective neck dissection for the management of the N0 neck in early cancer of the oral tongue: need for a randomized controlled trial. Head Neck, 31, 618-24. https://doi.org/10.1002/hed.20988
  4. D'Cruz AK, Vaish R, Kapre N, et al (2015). Elective versus therapeutic neck dissection in node-negative oral cancer. N Engl J Med, 373, 521-9. https://doi.org/10.1056/NEJMoa1506007
  5. Denis F, Garaud P, Bardet E, et al (2004). Final results of the 94-01 french head and neck oncology and radiotherapy group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma. J ClinOncol, 22, 69-76. https://doi.org/10.1200/JCO.2004.08.021
  6. Dimri K, Pandey AK, Trehan R, Rai B, Kumar A (2013). Conventional radiotherapy with concurrent weekly cisplatin in locally advanced head and neck cancers of squamous cell origin - a single institution experience.Asian Pac J Cancer Prev, 14, 6883-88. https://doi.org/10.7314/APJCP.2013.14.11.6883
  7. Ferlay J, Soerjomataram I, Ervik M, et al (2013). Cancer Incidence and Mortality Worldwide: GLOBOCAN 2012 v1.0, IARC Cancer Base No. 11 [Internet]. Lyon, France,
  8. Forastiere AA, Goepfert H, Maor M, et al (2003). Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med, 349, 2091-8. https://doi.org/10.1056/NEJMoa031317
  9. Gupta S, Khan H, Barik S, Negi MPS(2013). Clinical benefits of concurrent capecitabine and cisplatin versus concurrent cisplatin and 5-flurouracil in locally advanced squamous cell head and neck cancer. Drug Discoveries Therapeutics, 7, 36-42.
  10. Haddadin KJ, Soutar DS, Oliver RJ, et al, (1999). Improved survival for patients with clinically T1/T2, N0 tongue tumors undergoing a prophylactic neck dissection. Head Neck, 21, 517-25. https://doi.org/10.1002/(SICI)1097-0347(199909)21:6<517::AID-HED4>3.0.CO;2-C
  11. Huang SF, Kang CJ, Chen-Yu, et al (2008). Neck treatment of patients with early stage oral tongue. Cancer, 112, 1066-75. https://doi.org/10.1002/cncr.23278
  12. International statistical classification of Diseases 10th Revision. World Health Organization. 2010.
  13. Kaplan EL, Meier P (1958). Nonparametric estimation from incomplete observations. J Am Stat Assoc, 53, 457-81. https://doi.org/10.1080/01621459.1958.10501452
  14. Lasrado S, Moras K, Pinto G, et al (2014). Role of concomitant chemoradiation in locally advanced head and neck cancers. Asian Pac J Cancer Prev, 15, 4147-52. https://doi.org/10.7314/APJCP.2014.15.10.4147
  15. Matsuzuka T, Suzuki M, Saijo S, et al (2014). Usefulness of sentinel node navigation surgery in the management of early tongue cancer. AurisNasus Larynx, 41, 475-8.
  16. Nandakumar A (1993). Strategy for active follow-up in conduct of survival studies. presented at the annual review meeting of national cancer registry programme of India (ICMR), Dibrugarh India.
  17. Nandakumar A, Gupta PC, Gangadharan P,Visweswara RN (2005). Geographic Pathology revisited: Development of an Atlas of Cancer in India. Int J Cancer, 116, 740-54. https://doi.org/10.1002/ijc.21109
  18. Nandakumar A, Rath GK, Kataki AC, et al (2015). Concurrent chemoradiation for cancer of the cervix: results of a multiinstitutional study from the setting of a developing country (India). J Glob Oncol, 1, 11-22. https://doi.org/10.1200/JGO.2015.000877
  19. National Centre for Disease Informatics and Research, National Cancer Registry Programme (ICMR) (2013)-Consolidated report of Hospital Based Cancer Registries: (1984- 1993),(1994-1998), (1999-2000), (2001-2003), (2004-2006), (2007-2011), Bangalore, India.
  20. National Centre for Disease Informatics and Research, National Cancer Registry Programme (ICMR) (2013)-Time trends in cancer incidence rates 1982-2010, Bangalore, India.
  21. Pandey KC, Revannasiddaiah S, Pant NK, Bhatt HC (2014). Stage-wise presentation of non-metastatic head and neck cancer: an analysis of patients from the kumaon Hills of India. Asian Pac J Cancer Prev, 15, 4957-61. https://doi.org/10.7314/APJCP.2014.15.12.4957
  22. Rao DN, Shroff PD, Chattopadhyay G, Dinshaw KA (1998). Survival analysis of 5595 head and neck cancers results of conventional treatment in a high-risk population. British J Cancer, 77, 1514-18. https://doi.org/10.1038/bjc.1998.249
  23. Razak AA, Saddki N, Naing NN, Abdullah N (2010). Oral cancer survival among Malay Patients in Hospital UniversitiSains Malaysia, Kelantan. Asian Pac J Cancer Prev, 11, 187-91.
  24. Sharma JD, Krishnatreya M, Das AK, et al (2015). Radiotherapy and Concurrent Chemo-Radiotherapy in Locally Advanced Hypopharyngeal Cancers - A Hospital Registry Based Analysis. Asian Pac J Cancer Prev, 16, 4723-26. https://doi.org/10.7314/APJCP.2015.16.11.4723
  25. Sobin L, Gospodarowicz M, Wittekind C (2009). TNM classification of malignant tumours, seventh edition, International union against cancer.
  26. Yuen AP, Wei WI, Wong YM, Tang KC (1997). Elective neck dissection versus observation in the treatment of early oral tongue carcinoma. Head Neck, 19, 583-8. https://doi.org/10.1002/(SICI)1097-0347(199710)19:7<583::AID-HED4>3.0.CO;2-3
  27. Yuen AP, Ho CM, Chow TL (2009). Prospective randomized study of selective neck dissection versus observation for N0 neck of early tongue carcinoma. Head Neck, 31, 765-72. https://doi.org/10.1002/hed.21033

Cited by

  1. Role of benzydamine hydrochloride in the prevention of oral mucositis in head and neck cancer patients treated with radiotherapy (>50 Gy) with or without chemotherapy vol.25, pp.5, 2017, https://doi.org/10.1007/s00520-016-3548-9
  2. Systematic review of the use of big data to improve surgery in low- and middle-income countries vol.106, pp.2, 2019, https://doi.org/10.1002/bjs.11052