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Quality of Life among Breast Cancer Patients In Malaysia

  • Ganesh, Sri (Department of Community Health, University Putra Malaysia) ;
  • Lye, Munn-Sann (Department of Community Health, University Putra Malaysia) ;
  • Lau, Fen Nee (National Cancer Institute)
  • Published : 2016.06.01

Abstract

Background: Among the factors reported to determine the quality of life of breast cancer patients are socio-demographic background, clinical stage, type of treatment received, and the duration since diagnosis. Objective: The objective of this study was to determine the quality of life (QOL) scores among breast cancer patients at a Malaysian public hospital. Materials and Methods: This cross-sectional study of breast cancer patients was conducted between March to June 2013. QOL scores were determined using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and its breast cancer supplementary measure (QLQ-BR23). Both the QLQ-C30 and QLQ-BR23 assess items from functional and symptom scales. The QLQ-C30 in addition also measures the Global Health Status (GHS). Systematic random sampling was used to recruit patients. Results: 223 breast cancer patients were recruited with a response rate of 92.1%. The mean age of the patients was 52.4 years (95% CI = 51.0, 53.7, SD=10.3). Majority of respondents are Malays (60.5%), followed by Chinese (19.3%), Indians (18.4%), and others (1.8%). More than 50% of respondents are at stage III and stage IV of malignancy. The mean Global Health Status was 65.7 (SD = 21.4). From the QLQ-C30, the mean score in the functioning scale was highest for 'cognitive functioning' (84.1, SD=18.0), while the mean score in the symptom scale was highest for 'financial difficulties' (40.1, SD=31.6). From the QLQ-BR23, the mean score for functioning scale was highest for 'body image' (80.0, SD=24.6) while the mean score in the symptom scale was highest for 'upset by hair loss' (36.2, SD=29.4). Two significant predictors for Global Health Status were age and employment. The predictors explained 10.6% of the variation of global health status ($R^2=0.106$). Conclusions: Age and employment were found to be significant predictors for Global Health Status (GHS). The Quality of Life among breast cancer patients reflected by the GHS improves as age and employment increases.

Keywords

EORTC;quality of life;breast cancer;Malaysia

References

  1. Aaronson NK, Ahmedzai S, Bergman B, et al (1993). The European Organisation for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst, 85, 365-76. https://doi.org/10.1093/jnci/85.5.365
  2. Ariffin OZ, Nor Saleha IT (2007). NCR Report 2007. National Cancer Registry Report, Ministry of Health, Malaysia.
  3. Dennerstein L, Dudley EC, Hopper JL (2000). A prospective population-based study of menopausal symptoms. Obstet Gynecol, 96, 351-8.
  4. Fayers PM, Aaronson NK, Bjordal K et al (2001) on behalf of the EORTC quality of life group. The EORTC QLQ-C30 scoring manual (3rd Edition) published by european organisation for research and treatment of cancer, brussels.
  5. Ganz PA, Katherine A. Desmond et al (2002). Quality of life in long-term, disease-free survivors of breast cancer: a followup study. J Natl Cancer Inst, 94, 39-49. https://doi.org/10.1093/jnci/94.1.39
  6. Jassim GA, Whitford DL (2013). Quality of life of Bahraini women with breast cancer: a cross sectional study. BMC Cancer, 13, 212. https://doi.org/10.1186/1471-2407-13-212
  7. Goodwin PJ, Ennis M, Pritchard KI et al (1999). Risk of menopause during the first year after breast cancer diagnosis. J Clin Oncol, 17, 2365-2370. https://doi.org/10.1200/JCO.1999.17.8.2365
  8. Hisham AN, Yip CH (2004). Overview of breast cancer in Malaysian women: a problem with late diagnosis. Asian J Surg, 27, 130-3. https://doi.org/10.1016/S1015-9584(09)60326-2
  9. Hwa YS, Hashim A (2011). The socioeconomic impacts of breast cancer on breast cancer patients in Penang. Kajian Malaysia, 29, 111-36.
  10. Ferlay J, Soerjomataram I, Dikshit R, et al (2015). Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012, Int J Cancer, 136, 359-86. https://doi.org/10.1002/ijc.29210
  11. Jessica HA, Patricia AG, Bower JE, et al (2012). Quality of life, fertility concerns, and behavioral health outcomes in younger breast cancer survivors: A systemic review. J Natl Cancer Inst, 104, 1-20.
  12. Lim GC, Azura D (2008). National cancer patient registry-a patient registry/clinical database to evaluate the health outcomes of patients undergoing treatment for cancers in Malaysia. Med J Malaysia, 63, 55-6.
  13. Mor V, Malin M, Allen S (1994). Age differences in the psychosocial problems encountered by breast cancer patient. J Natl Cancer Inst Monogr, 16, 191-7.
  14. Mvila GL, Postema S, Marchal G, et al (2014). From the setup of a screening program of breast cancer patients to the identification of the first BRCA mutation in the DR Congo, BMC Public Health, 14, 759. https://doi.org/10.1186/1471-2458-14-759
  15. Perry SH, Kowalski TL, Chang CH (2007). Quality of life assessment in women with breast cancer: benefits, acceptability and utilization. Health Qual Life Outcomes 5, 24-38. https://doi.org/10.1186/1477-7525-5-24
  16. Saleha SB, Shakeel A, Shumaila E et al (2010). An Assessment of Quality of life in breast cancer patients using EORTC QLQ C30/+BR23 Questionnaire. Iranian J Cancer Prev, 2, 98-104.
  17. Shoshana M.R, Ann H. Partridge (2013). Premature menopause in young breast cancer: effects on quality of life and treatment interventions; J Thorac Dis, 5, 55-61.
  18. Sukumvanich P, Case LD, Van Zee K, et al (2010). Incidence and time course of bleeding after long term amenorrhea after breast cancer treatment: a prospective study. Cancer, 116, 3102-11. https://doi.org/10.1002/cncr.25106
  19. Wong-Kim E, Sun A, Merighi JR et al (2005). Understanding quality-of-life issues in Chinese women with breast cancer: a qualitative investigation. Cancer Control, 12, 6-12. https://doi.org/10.1177/1073274805012004S02
  20. Yip CH, NA Mohd Taib, Ibrahim Mohamed (2006). Epidemiology of breast cancer in Malaysia. Asian Pac J Cancer Prev, 7, 369-74.
  21. Yusoff N, Low WY, Yip CH (2010). The Malay version of the European organization for research and treatment of cancer quality of life questionnaire (EORTC-QLQ C30): realibility and validity study. Int Med J Malaysia, 9, 45-50.
  22. Yusoff N, Low W, Yip C (2012). Psychometric properties of the Malay version of the breast module (BR23). Singapore Med J, 53, 36.

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