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Clinical Features of Oxaliplatin Induced Hypersensitivity Reactions and Therapeutic Approaches

  • Bano, Nusrat (Pharmacology, King Saud bin Abdulaziz University of Health Sciences) ;
  • Najam, Rahila (Pharmacology, University of Karachi) ;
  • Qazi, Faaiza (Pharmaceutics, Jinnah Sindh Medical University) ;
  • Mateen, Ahmed (Clinical Oncology, Karachi Institute of Radiotherapy and Nuclear Medicine (KIRAN))
  • Published : 2016.06.01

Abstract

Oxaliplatin, a third generation novel platinum compound is the most effective first line chemotherapeutic agent for colorectal cancer (CRC) in combination with 5FU and leucovorin. It is indicated for pancreatic, gastric and testicular cancers combined with bevacuzimab, capecitabine, irinotecan and other cytotoxic agents. However, moderate to severe hypersensitivity reactions (HSR) during or after oxaliplatin infusion usually require cessation of chemotherapy or substitution of the key therapeutic drug which largely interferes with improved patient prognosis. This mini- review showcases recent and accepted opinions/approaches in oxaliplatin induced HSR management. Physicians and oncologists have varying attitudes regarding the decision to rechallenge the patient after an HSR experience, efficacy of desensitization protocols, effectiveness and selection of drugs for premedication and possibilities of cross sensitivity to other platinum agents (e.g. carboplatin). A brief insight into underlying molecular mechanisms and clinical manifestations of oxaliplatin induced HSR is offered. We have also discussed the management of oxaliplatin induced HSR and risk stratification for a successful and complete chemotherapeutic plan.

Keywords

Oxaliplatin;hypersensitivity reactions;desensitization;management;rechallenge

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