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A Case Report of Recurred Hepatocellular Carcinoma Patient Treated with Radio-Frequency Hyperthermia in Conjunction with Sorafenib

고주파 온열치료와 소라페닙을 병용하여 호전된 재발성 간암환자 1례

  • Kim, Jee-Hye (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Lee, Jong-Hoon (Integrative Cancer Center, Woosuk Korean Medicine Hospital of Woosuk University) ;
  • Joo, Jong-Cheon (Integrative Cancer Center, Jeonju Korean Medicine Hospital of Wonkwang University) ;
  • Lee, Jeong-Bok (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Cho, Chong-Kwan (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Yoo, Hwa-Seung (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University)
  • 김지혜 (대전대학교 둔산한방병원 동서암센터) ;
  • 이종훈 (우석대학교 한방병원 통합암센터) ;
  • 주종천 (원광대학교 전주한방병원 통합암센터) ;
  • 이정복 (대전대학교 둔산한방병원 동서암센터) ;
  • 조종관 (대전대학교 둔산한방병원 동서암센터) ;
  • 유화승 (대전대학교 둔산한방병원 동서암센터)
  • Received : 2016.11.18
  • Accepted : 2016.12.05
  • Published : 2016.12.30

Abstract

Objective : The purpose of this study is to report the effects of radio-frequency hyperthermia cancer treatment in conjunction with Sorafenib on hepatocellular carcinoma patient. Method : The patient was diagnosed with hepatocellular carcinoma at S6/7 and treated with right posterior sectionectomy. After 4 months, tumor recurrence was found at S4, 5 and 8. After transarterial chemoembolization, the patient was prescribed Sorafenib (proprietary name $Nexavar^{(R)}$ ) as well as proceeding with radio-frequency hyperthermia. The clinical outcomes were measured by computed tomography, laboratory findings including tumor markers (AFP, PIVKA-II), natural killer (NK) cell activity, and numeric rating scales (NRS). Results : After the treatment, tumor size was decreased accompanying by reducing the level of tumor markers (AFP, PIVKA-II). Major clinical symptoms were improved with increasing NK cell activity. There were no adverse events based on National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. Conclusion : This case suggests that radio-frequency hyperthermia has synergistic effect for the treatment of hepatocellular carcinoma patient in conjunction with Sorafenib.

Acknowledgement

Supported by : 대전대학교

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