DOI QR코드

DOI QR Code

Accuracy, Sensitivity and Specificity of Fine Needle Aspiration Biopsy for Salivary Gland Tumors: A Retrospective Study from 2006 to 2011

  • Silva, William P P (Erasto Gaertner Hospital) ;
  • Stramandinoli-Zanicotti, Roberta T (Erasto Gaertner Hospital) ;
  • Schussel, Juliana L (Erasto Gaertner Hospital) ;
  • Ramos, Gyl H A (Erasto Gaertner Hospital) ;
  • Ioshi, Sergio O (Erasto Gaertner Hospital) ;
  • Sassi, Laurindo M (Erasto Gaertner Hospital)
  • Published : 2016.11.01

Abstract

Objective: This article concerns evaluation of the sensitivity, specificity and accuracy of FNAB for pre-surgical diagnosis of benign and malignant lesions of major and minor salivary glands of patients treated in the Department of Head and Neck Surgery of Erasto Gartner Hospital. Methods: This retrospective study analyzed medical records from January 2006 to December 2011 from patients with salivary gland lesions who underwent preoperative FNAB and, after surgical excision of the lesion, histopathological examination. Results: The study had a cohort of 130 cases, but 34 cases (26.2%) were considered unsatisfactory regarding cytology analyses. Based on the data, sensitivity was 66.7% (6/9), specificity was 81.6% (71/87), accuracy was 80.2% (77/96), the positive predictive value was 66,7% (6/9) and the negative predictive value was 81.6% (71/87). Conclusion: Despite the high rate of inadequate samples obtained in the FNAB in this study the technique offers high specificity, accuracy and acceptable sensitivity.

Keywords

Salivary Gland Tumor;fine-needle aspiration;sensitivity;accuracy;specificity

References

  1. Adisa AO, Oluwasola AO, Adeyemi BF, et al (2010). Immunohistochemical analysis of undifferentiated and poorly-differentiated head and neck malignancies at a tertiary hospital in Nigeria. Head Neck Oncol, 2, 33. https://doi.org/10.1186/1758-3284-2-33
  2. Colella G, Cannavale R, Flamminio F, Foschini MP(2010). Fine-needle aspiration cytology of salivary gland lesions: a systematic review. J Oral Maxillofac Surg, 68, 2146-3. https://doi.org/10.1016/j.joms.2009.09.064
  3. Cross DL, Gansler TS, Morris RC (1990). Fine needle aspiration and frozen section of salivary gland lesions. South Med J, 83, 283-6. https://doi.org/10.1097/00007611-199003000-00007
  4. Derin S, Erdogan S, Almac A, et al (2015). Parotid gland tumours in Turkish population: analysis of 165 patients. Asian Pac J Cancer Prev, 16, 3539-2. https://doi.org/10.7314/APJCP.2015.16.8.3539
  5. Frankel PP, Esteves VF, Thuler LCS, VieiraR JDS (2011). Acuracia da puncao aspirativa por agulha fina e da puncao por agulha grossa no diagnostico de lesoes mamarias. Rev Bras de Ginecol e Obstet, 33, 139-3. https://doi.org/10.1590/S0100-72032011000300007
  6. Howlett DC, Skelton E, Moody AB (2015). Establishing an accurate diagnosis of a parotid lump: evaluation of the current biopsy methods - fine needle aspiration cytology, ultrasound-guided core biopsy, and intraoperative frozen section. Br J Oral Maxillofac Surg, 53, 580-3. https://doi.org/10.1016/j.bjoms.2015.03.015
  7. Jaafari-Ashkavandi Z, Ashraf MJ, Moshaverinia M (2013). Salivary gland tumors: a clinicopathologic study of 366 cases in southern Iran. Asian Pac J Cancer Prev, 14, 27-9. https://doi.org/10.7314/APJCP.2013.14.1.27
  8. Kesse KW, Manjaly G, Violaris N, Howlett DC (2002). Ultrasound-guided biopsy in the evaluation of focal lesions and diffuse swelling of the parotid gland. Br J Oral Maxillofac Surg, 40, 384-8. https://doi.org/10.1016/S0266-4356(02)00189-4
  9. Mejia-Velazquez CP, Duran-Padilla MA, Gomez-Apo E, Quezada-Rivera D, Gaitan-Cepeda LA (2012). Tumors of the salivary gland in Mexicans. A retrospective study of 360 cases. Med Oral Patol Oral Cir Bucal, 17, 183-9.
  10. Nelson BL, Thompson LDR (2012). Incisional or core biopsies of salivary gland tumours: how far should we go? Diagn Histopathol, 18, 358-5. https://doi.org/10.1016/j.mpdhp.2012.08.003
  11. Nguansangiam S, Jesdapatarakul S, Dhanarak N, Sosrisakorn K (2012). Accuracy of fine needle aspiration cytology of salivary gland lesions: routine diagnostic experience in Bangkok, Thailand. Asian Pac J Cancer Prev, 13, 1583-8. https://doi.org/10.7314/APJCP.2012.13.4.1583
  12. Pfeiffer J, Ridder GJ (2012). Diagnostic value of ultrasound-guided core needle biopsy in patients with salivary gland masses. Int J Oral Maxillofac Surg, 41, 437-3. https://doi.org/10.1016/j.ijom.2011.12.005
  13. Saha S, Woodhouse NR, Gok G, et al (2011). Ultrasound guided core biopsy, fine needle aspiration cytology and surgical excision biopsy in the diagnosis of metastatic squamous cell carcinoma in the head and neck: an eleven year experience. Eur J Radiol, 80, 792-5. https://doi.org/10.1016/j.ejrad.2010.10.020
  14. Saleh HA, Clayman L, Masri H (2008). Fine needle aspiration biopsy of intraoral and oropharyngeal mass lesions. Cytojournal, 5, 4. https://doi.org/10.1186/1742-6413-5-4
  15. Santos AP, Sugaya NN, Pinto Junior S, Lemos Junior CA (2011). Fine needle aspiration biopsy in the oral cavity and head and neck region. Braz Oral Res, 25, 186-1. https://doi.org/10.1590/S1806-83242011000200015
  16. Schmidt RL, Factor RE, Witt BL, Layfield LJ (2013). Quality appraisal of diagnostic accuracy studies in fineneedle aspiration cytology: a survey of risk of bias and comparability." Arch Pathol Lab Med, 137, 566-5. https://doi.org/10.5858/arpa.2012-0199-RA
  17. Shishegar M, Ashraf MJ, Azarpira N, et al (2011). Salivary gland tumors in maxillofacial region: a retrospective study of 130 cases in a southern Iranian population. Patholog Res Int, 9, 343-0.
  18. Singh Nanda KD, Mehta A, Nanda J (2012). Fine-needle aspiration cytology: a reliable tool in the diagnosis of salivary gland lesions. J Oral Pathol Med, 41, 106-2. https://doi.org/10.1111/j.1600-0714.2011.01069.x
  19. Stramandinoli RT, Sassi LM, Pedruzzi PA, et al (2009). Accuracy, sensitivity and specificity of fine needle aspiration biopsy in salivary gland tumours: A retrospective study. Med Oral Patol Oral Cir Bucal, 15, 32-7.
  20. Vaidya S, Sinha A, Narayan S, Adhikari S, Sabira K (2011). A comparative study of fine-needle aspiration cytology and histopathology in salivary gland lesions. J Pathol Nepal, 1, 108-3.
  21. Wang YL, Zhu YX, Chen TZ, et al (2012). Clinicopathologic study of 1176 salivary gland tumors in a Chinese population: experience of one cancer center 1997-2007. Acta Otolaryngol, 132, 879-6.
  22. Zerpa Zerpa V, Gonzales MTC, Porras GA, et al (2014). Diagnostic Accuracy of Fine Needle Aspiration Cytology in Parotid Tumours. Acta Otorrinolaringol Eng, 65, 157-1. https://doi.org/10.1016/j.otorri.2013.12.002