- Volume 17 Issue 11
DOI QR Code
Elevated Expression of Ox2R in Cervical Cancers and Placentas of Uyghur Women in Xinjiang, China
- Taximaimaiti, Reyisha (Seven-year Clinical Medicine of Class 2) ;
- Abuliken, Xiekelai (Seven-year Clinical Medicine of Class 2) ;
- Maihemuti, Muzhapaer (Seven-year Clinical Medicine of Class 2) ;
- Abudujilile, Dilinuer (Seven-year Clinical Medicine of Class 2) ;
- Abudulimu, Haimiti (Department of Histology and Embryology, Xinjiang Medical University)
- Published : 2016.11.01
Objective:Cervical cancer is one of the major causes of mortality of Uyghur women in Xinjiang, China. Although increased expression of orexin receptor (OxR), known to be strongly expressed in human placenta, has a proven relation to some cancers, there have been few studies of cervical cancer. Thus, we explored this question by evaluating the expression of orexin receptor as a biomarker for screening early stage of cervical cancer in Uyghur women with highest occurrence rate of cervical cancer in China. Study Design: We used polymerase chain reaction (PCR) and immunohistochemical staining to determine the expression of both Ox1R and Ox2R in cervical cancer and cervicitis biopsies collected from Uyghur women infected with human papilloma virus (HPV)16. The expression rate was compared between cervical cancers of low, intermediate and high differentiation and cervicitis. Results:Although there was no significant difference in the expression rate of Ox1R between groups, Ox2R was significantly overexpressed in cervical cancer patients when compared to the cervicitis group. Ox1R was negative in normal human placenta while Ox2R was positive. Conclusions: While expression of Ox1R had no correlation with invasion or metastatic potential, Ox2R demonstrated elevation in cervical cancer with heterogeneity in groups with different metastatic potential, in the human placenta as well, implying that it might serve as an indicator of invasive capacity along with other indices.
Ox1R;Ox2R;cervical cancer;HPV16;human placenta
Supported by : Xinjiang Medical University
- Basar MM, Han U, Cakan M, Alpcan S, Basar H (2013). Orexin expression in different prostate histopathologic examinations: Can it be a marker for prostate cancer? A preliminary result. Turk J Urol, 39, 78-83. https://doi.org/10.5152/tud.2013.023
- Biedermann K, Dandachi N, Trattner M, et al.(2004). Comparison of real-time PCR signal-amplified in situ hybridization and conventional PCR for detection and quantification of human papillomavirus in archival cervical cancer tissue. J Clin Microbiol, 42, 3758-65. https://doi.org/10.1128/JCM.42.8.3758-3765.2004
- Cataldi NI, Lux-Lantos V, Libertun C (2012). Effects of orexins A and B on expression of orexin receptors and progesterone release in luteal and granulosa ovarian cells. Regul Pept, 178, 56-63. https://doi.org/10.1016/j.regpep.2012.06.008
- Chen W, Cao G, Zhang SL (2011). Is CD146 pivotal in neoplasm invasion and blastocyst embedding? Med Hypotheses, 76, 378-80. https://doi.org/10.1016/j.mehy.2010.10.045
- Dehan P, Canon C, Trooskens G, et al (2013). Expression of type 2 orexin receptor in human endometrium and its epigenetic silencing in endometrial cancer. J Clin Endocrinol Metab, 98, 1549-57. https://doi.org/10.1210/jc.2012-3263
- Fang LQ, Zhang H, Ding XY, et al (2010). Mouse trophoblastic cells exhibit a dominant invasiveness phenotype over cancer cells. Cancer Lett, 299, 111-8. https://doi.org/10.1016/j.canlet.2010.08.008
- Haimiti A, Hailiman Y, Gulina A, et al (2014). Reduced expression of members of the mhc-i antigen processing machinery in ethnic Uighur women with cervical cancer in the Xinjiang region of China. CURR ONCOL, 21, e67-74.
- Husnjak K, Grce M, Magdic L, Pavelic K(2000). Comparison of five different polymerase chain reaction methods for detection of human papillomavirus in cervical cell specimens. J Virol Methods, 88, 125-34. https://doi.org/10.1016/S0166-0934(00)00194-4
- Jiang SQ. Wang T, Tu S, et al (2006). Epideunidogical investigation and analysis of cervical carcinoma in Cele county of Xinjiang[Chinese]. Chin J Prac Gynecol Obstetr, 22, 379-81.
- Jiang SQ, Wang T, Tu S (2006). Investigation of cervical cancer in Cele county of Xinjiang, China [Chinese]. Chin J Pract Gynecol Obstet, 22, 79-81.
- Kishida M, Ishige K, Horibe T, et al (2012). Orexin 2 receptor as a potential target for immunotoxin and antibody-drug conjugate cancer therapy. Oncol Lett, 3, 525-9. https://doi.org/10.3892/ol.2011.528
- Laburthe M, Voisin T, Firar AE (2010). REVIEW:Orexins/hypocretins and orexin receptors in apoptosis: a mini-review. Acta Physiol, 198, 393-402. https://doi.org/10.1111/j.1748-1716.2009.02035.x
- Malczewska-Lenczowska J, Orysiak J, Majorczyk E, et al. (2014).No association betWEEN tHbmass AND polymorphisms in the HBB gene in endurance athletes. Biol Sport, 31, 115-9. https://doi.org/10.5604/20831862.1099372
- Mo LZ, Song HL, Wang JL, et al (2015). Pap smear combined with HPV testing: A reasonable tool for women with highgrade cervical intraepithelial neoplasia treated by LEEP. Asian Pac J Cancer Prev, 16, 4297-302. https://doi.org/10.7314/APJCP.2015.16.10.4297
- Nesic AR, Kokunesoski MJ, Volkov-Husovic TD, Velickovic SJ (2016). New method for quantification of dye sorption using SBA mesoporous silica as a target sorbent. Environ Monit Assess, 188, 160. https://doi.org/10.1007/s10661-016-5155-0
- Parkin DM, Bray F, Ferlay J, Pisani P (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55, 74-108. https://doi.org/10.3322/canjclin.55.2.74
- Voisin T, Rouet-Benzineb P, Reuter N, Laburthe M (2003). Orexins and their receptors: structural aspects and role in peripheral tissues. Cell Mol Life Sci, 60, 72-87. https://doi.org/10.1007/s000180300005
- Voisin T, Firar AE, Avondo V, Laburthe M (2003). Orexin-Induced Apoptosis: The Key Role of the Seven- Transmembrane Domain Orexin Type 2 Receptor. J Endocrinol, 147, 4977-84.